MirabegronA β3 adrenergic receptor agonist of bladder muscles

Mirabegron (CAS 223673-61-8)

Mirabegron | CAS 223673-61-8 is rated 5.0 out of 5 by 1.
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Synonym: 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Application: A β3 adrenergic receptor agonist of bladder muscles
CAS Number: 223673-61-8
Molecular Weight: 396.51
Molecular Formula: C21H24N4O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mirabegron is a potent bladder relaxant. The compound activates the β3 adrenergic receptor in the detrusor muscle in the bladder leading to relaxation of the bladder muscles.

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
138-140° C
Boiling Point :
~690.0° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9865528
SMILES :
NC1=NC(CC(=O)NC2=CC=C(CCNCC(O)C3=CC=CC=C3)C=C2)=CS1

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Certificate of Analysis

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Mirabegron  Product Citations

See how others have used Mirabegron. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30541923  Adachi, N.|Hess, DT.|Kaku, M.|Ueda, C.|Numa, C.|Saito, N.| et al. 2019. J. Biol. Chem. 294: 2569-2578.

PMID: # 30032151  Milano, S.|Gerbino, A.|Schena, G.|Carmosino, M.|Svelto, M.|Procino, G.| et al. 2018. Cell. Physiol. Biochem. 48: 847-862.

PMID: # 25861936  D' Agostino, G. et al. 2015. European journal of pharmacology. 758: 115-22.

Citations 1 to 3 of 3 total

What is the solubility of this compound?

Asked by: two2igm05
The solvents of this compound are chloroform and methanol (~5 mg/mL).
Answered by: Chemical Support 4
Date published: 2017-02-28

The product is stored at 4° C for about a year, is the material still useable at this point?

Asked by: two2igm05
Thank you for your question. We recommend our customers to store this chemical at -20° C and we cannot guarantee the quality of the material if the chemical is not stored at what we suggest. If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2016-12-28
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Rated 5 out of 5 by from Yuno Yuno, K. et al. (PubMed 24849685) investigated the effect of Mirabegron on plasma gonadotropic and steroidal hormone levels in rats after two weeks of oral administration. They found that Mirabegron has no effect on gonadotropic or sex steroidal hormone levels -SCBT Publication Review
Date published: 2015-04-15
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