Minoxidil (U-10858)A selective ATP dependent K+ (Kir6) channel activator

Minoxidil (U-10858) (CAS 38304-91-5)

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Synonym: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide; 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide
Application: A selective ATP dependent K+ (Kir6) channel activator
CAS Number: 38304-91-5
Molecular Weight: 209.3
Molecular Formula: C9H15N5O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the β-catenin pathway in human dermal papilla cells which results in accumulation of β-catenin in the nucleus.


1. Meisheri, K.D., et al. 1988. J. Pharmacol. Exp. Ther. 245: 751-760. PMID: 3385640
2. Kwack, M.H., et al. 2011. J. Dermatol. Sci. 62: 154-159. PMID: 21524889

Physical State :
Solubility :
Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Storage :
Store at room temperature
Melting Point :
272-274° C (dec.)
Boiling Point :
~351.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
pK Values :
pKa: 4.61
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 6203
MDL Number :
EC Number :

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Certificate of Analysis

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