MilrinoneA phosphodietsterase 3 inhibitor

Milrinone (CAS 78415-72-2)

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Synonym: 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile
Application: A phosphodietsterase 3 inhibitor
CAS Number: 78415-72-2
Purity: ≥98%
Molecular Weight: 211.22
Molecular Formula: C12H9N3O
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Milrinone is a PDE3 (phosphodiesterase 3) inhibitor that exhibits vasodilator and positive inotropic effects. Milrinone's positive inotropic activity can be inhibited by carbachol (sc-202092). Research indicates that Milrinone can increase platelets and enhance cAMP levels. Milrinone is an inhibitor of PDE3A and PDE3B.


References

1. Harrison, S.A., et al. 1986. Mol. Pharmacol. 29: 506-514. PMID: 3010079
2. Lindgren, S.H., et al. 1990. Acta Physiol. Scand. 140: 209-219. PMID: 2176433
3. Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20: 705-714. PMID: 1280731
4. Bailey, J.M., et al. 1994. Anesthesiology. 81: 616-622. PMID: 8092507
5. Sällström, J., et al. 2010. Am J Hypertens. PMID: 20651700

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), warm 100% ethanol (3 mg/ml), and DMF (~0.3 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
>280° C
Boiling Point :
~448.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
PDE3: IC50 = 0.3 µM; PDE3A: IC50 = 0.45 µM; PDE3B: IC50 = 1.0 µM; PDE1: IC50 = 263 µM; PDE2: IC50 = >300 µM; PDE4: IC50 = 17.5 µM; PDE5: IC50 = 49.1 µM; PDE7: IC50 = 58.3 µM
Ki Data :
Phosphodiesterase 3A: Ki= 150 nM (human); Phosphodiesterase 3B: Ki= 150 nM (human)
pK Values :
pKa: 7.21 (Predicted), pKb: 5.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DW1762000
PubChem CID :
4197
Merck Index :
14: 6197
MDL Number :
MFCD00133539
EC Number :
278-903-6
Beilstein Registry :
3546821
SMILES :
CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2

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Milrinone  Product Citations

See how others have used Milrinone. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27408772  Kolic, J. et al. 2016. Mol Metab. 5: 459-71.

PMID: # 27342776  Prysyazhna, O. et al. 2016. J. Biol. Chem. 291: 17427-36.

PMID: # 25843350  Kim, T. et al. 2015. Metab. Eng. 29: 169-79.

PMID: # 23656623  Ikari, J. et al. 2013. Am. J. Respir. Cell Mol. Biol. 49: 571-81.

PMID: # 14500395  Strock, CJ. et al. 2003. Cancer Res. 63: 5559-63.

Citations 1 to 5 of 5 total
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