Milameline hydrochlorideCAS: 139886-32-1
MF: C8H14N2O•HCl
MW: 190.67
A muscarinic receptor agonist.

Milameline hydrochloride (CAS 139886-32-1)

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Application: A muscarinic receptor agonist
CAS Number: 139886-32-1
Purity: ≥99%
Molecular Weight: 190.67
Molecular Formula: C8H14N2O•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Milameline hydrochloride is a muscarinic receptor agonist that displays roughly equal affinity at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for mAChR M1, mAChR M2, mAChR M3, mAChR M4, mAChR M5 (hM1, hM2, hM3, hM4 and hM5 receptors) respectively). Cognitive enhancer; reverses spatial memory deficits in rats.


References

Sedman et al (1995) Preclinical and phase I clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease. Life Sci. 56 877. Wood et al (1999) Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry. Br.J.Pharmacol. 126 1620. Schwarz et al (1999) Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J.Pharmacol.Exp.Ther. 291 812.

Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Desiccate at -20° C
Refractive Index :
n20D ~1.50 (Predicted)
IC50 :
Muscarinic acetylcholine receptor: IC50 = 110 nM (rat)
Ki Data :
hM1 receptor: Ki= 2.3 µM; hM2 receptor: Ki= 2.4 µM; hM3 receptor: Ki= 3.6 µM; hM4 receptor: Ki= 3.8 µM; hM5 receptor: Ki= 4.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
US4356000
PubChem CID :
9571001
MDL Number :
MFCD00890867
SMILES :
CN1CCC=C(C1)/C=N/OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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