MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties. MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
1. Lubetsky, Jodi B., et al., 2002. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. The Journal of biological chemistry. 277(28): 24976-82. PMID: 11997397
2. Cvetkovic, Ivana., et al., 2005. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology. 146(7): 2942-51. PMID: 15790730
See how others have used MIF Antagonist, ISO-1. Click on the entry to view the PubMed entry .
PMID: # 29227009 Guo, ZD.|Zhao, L.|Wang, P.|Deng, WH.|Shi, Q.|Zuo, T.|Hong, YP.|Wang, WX.| et al. 2018. J. Obstet. Gynaecol. Res. 44: 374-383.
PMID: # 23411097 Wang, YZ. et al. 2013. Journal of neuroimmunology. 257: 67-75.
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