MIF Antagonist, ISO-1A cell-permeable isoxazoline compound that displays anti-inflammatory properties

MIF Antagonist, ISO-1 (CAS 478336-92-4)

MIF Antagonist, ISO-1 | CAS 478336-92-4 is rated 5.0 out of 5 by 1.
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Synonym: Macrophage Migration Inhibitory Factor Antagonist; ISO-1; (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid
Application: A cell-permeable isoxazoline compound that displays anti-inflammatory properties
CAS Number: 478336-92-4
Purity: ≥95%
Molecular Weight: 235.24
Molecular Formula: C12H13NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties. MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 has been shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.


References

1. Lubetsky, Jodi B., et al., 2002. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. The Journal of biological chemistry. 277(28): 24976-82. PMID: 11997397
2. Cvetkovic, Ivana., et al., 2005. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology. 146(7): 2942-51. PMID: 15790730

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
Melting Point :
133.69° C (Predicted)
Boiling Point :
~337.6° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
D-dopachrome tautomerase: IC50 = 7 µM; MIF tautomerase activity: IC50 = 11 µM; spontaneous secretion/release/recognition of MIF: IC50 = 25 µM (human PBMC)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6098948
SMILES :
COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1

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MIF Antagonist, ISO-1  Product Citations

See how others have used MIF Antagonist, ISO-1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29227009  Guo, ZD.|Zhao, L.|Wang, P.|Deng, WH.|Shi, Q.|Zuo, T.|Hong, YP.|Wang, WX.| et al. 2018. J. Obstet. Gynaecol. Res. 44: 374-383.

PMID: # 23411097  Wang, YZ. et al. 2013. Journal of neuroimmunology. 257: 67-75.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Kouzoukas Kouzoukas, DE. et al. (PubMed 26020638) found that MIF Antagonist (ISO-1), an antagonist of macrophage migration inhibitory factor, eliminated PAR4- and reduced PAR1-induced hypersensitivity in both human urothelial cells in vitro and mouse urothelium in vivo. -SCBT Publication Review
Date published: 2015-04-29
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