Anti-mHMGCS Antibody (B-8) is a mouse monoclonal IgG2a κ mHMGCS antibody, cited in 2 publications, provided at 200 µg/ml
raised against amino acids 419-488 mapping near the C-terminus of mHMGCS of human origin
Anti-mHMGCS Antibody (B-8) is recommended for detection of mHMGCS of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-mHMGCS Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of mHMGCS (B-8): sc-393256.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for mHMGCS Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with mHMGCS Antibody (B-8) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
mHMGCS Antibody (B-8) is a high quality monoclonal mHMGCS antibody (also designated mHMGCS antibody) suitable for the detection of the mHMGCS protein of mouse, rat and human origin. mHMGCS Antibody (B-8) is available as both the non-conjugated anti-mHMGCS antibody form, as well as multiple conjugated forms of anti-mHMGCS antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rated 5 out of
Great in WB!Great antibody! It worked well in intestinal crypt cells.
Date published: 2019-04-01
Rated 5 out of
Produced positive Western Blot data of mHMGCSProduced positive Western Blot data of mHMGCS expression in non-transfected 293T, mouse mHMGCS transfected 293T and Caco-2 whole cell lysates. -SCBT QC
Date published: 2015-05-14
Rated 5 out of
Satisfactory Western Blot data of mHMGCSSatisfactory Western Blot data of mHMGCS expression in non-transfected and mouse mHMGCS transfected 293T whole cell lysates and mouse liver and human liver tissue extracts. -SCBT QC
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