mGluR5 Ligand, CDPPBA selective, reversible, positive allosteric modulator for mGluR-5

mGluR5 Ligand, CDPPB (CAS 781652-57-1)

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Synonym: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Application: A selective, reversible, positive allosteric modulator for mGluR-5
CAS Number: 781652-57-1
Molecular Weight: 364.4
Molecular Formula: C23H16N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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mGluR5 Ligand, CDPPB is a pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic mGluR-5 (glutamate receptor subtype 5). This also exerts anti-psychotic-like effects. It is reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR-5 cells (EC50 = 10 nM. It does not potentiate the activity of other glutamate receptors.


References

1. Lindsley, C.W., et al. 2004. J. Med. Chem. 47: 5825-5828. PMID: 15537338 2. Kinney, G.G., et al. 2005. J.Pharmacol. Exp. Ther. 313: 199-206. PMID: 15608073

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/mL).
Storage :
Store at 4° C
Melting Point :
264.38° C (Predicted)
Boiling Point :
523.28° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
mGluR-5: EC5050 = 10 nM (human receptor); mGluR-5: EC5050 = 20 nM (rat receptor )
Ki Data :
mGluR-5: Ki= 250 nM (human); mGluR-5: Ki= 3.76 µM (rat)
pK Values :
pKa: 11.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11245456
MDL Number :
MFCD12828752
SMILES :
C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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