MGD sodium salt monohydrateA useful component for the formation of the MGD2-Fe2+complex

MGD sodium salt monohydrate (CAS 91840-27-6)

MGD sodium salt monohydrate | CAS 91840-27-6 is rated 5.0 out of 5 by 1.
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Synonym: N-(Dithiocarbamoyl)-N-methyl-D-glucamine•Na•H20; N-Methyl-D-glucamine dithiocarbamate; N-(D-Glucityl)-N-methyldithiocarbamate sodium salt
Application: A useful component for the formation of the MGD2-Fe2+complex
CAS Number: 91840-27-6
Purity: ≥98%
Molecular Weight: 311.34
Molecular Formula: C8H16NO5S2•Na•H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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MGD sodium salt monohydrate is a useful component for the formation of the MGD2-Fe2+ complex, which is an excellent nitric oxide (NO) spin-trapping reagent. MGD2-Fe2+ complex is unstable thus, use immediately after being made. An excess of MGD to Fe2+ is used for making the complex with FeSO4 to create a more stable complex solution. Acidic conditions should be avoided because dithiocarbamate tends to decompose forming toxic carbon disulfide.


References

Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication: L.A. Shinobu, et al.; Acta Pharmacol. Toxicol. 54, 189 (1984) In vivo spin trapping of nitric oxide in mice: A. Komarov, et al.; BBRC 195, 1191 (1993) Spin trapping of nitric oxide produced in vivo in septic-shock mice: C.-S. Lei & A.M. Komarov; FEBS Lett. 345, 120 (1994) Spin trapping isotopically-labelled nitric oxide produced from [15N]L- arginine and [17O]dioxygen by activated macrophages using a water soluble Fe(++)-dithiocarbamate spin trap: Y. Kotake, et al.; Free Rad. Res. 23, 287 (1995) Continuous and quantitative monitoring of rate of cellular nitric oxide generation: Y. Kotake; Methods Enzymol. 268, 222 (1996) Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex: Y. Kotake, et al.; Biochim. Biophys. Acta 1289, 362 (1996) Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems: A.F. Vanin, et al.; Biochim. Biophys. Acta 1474, 365 (2000) Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase: A.M. Komarov, et al.; Free Radic. Biol. Med. 28, 793 (2000) Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR: S. Venkataraman, et al.; Free Radic. Biol. Med. 29, 580 (2000) EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell. Mol. Biol. Lett. 7, 142 (2002) Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate: C. Lu & W.H. Koppenol; Free Radic. Biol. Med. 39, 1581 (2005) Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006)

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
57369922
MDL Number :
MFCD01862580
SMILES :
CN([C@H]([C@@H]([C@H]([C@H](CO)O)O)O)O)C(=S)[S-].O.[Na+]

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MGD sodium salt monohydrate  Product Citations

See how others have used MGD sodium salt monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27112665  Hirsh, DJ. et al. 2016. Free radical biology & medicine. 96: 199-210.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of MGD Various publications cite the use of MGD sodium salt monohydrate as a component for the formation of the MGD2-Fe2+ complex, an excellent nitric oxide (NO) spin-trapping reagent. -SCBT Publication Review
Date published: 2015-02-20
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