Mezerein is a PKC (protein kinase C) activator. Second stage tumor promoter whereas phorbol-12-myristate 13-acetate (PMA) is a first stage tumor promoter. Mezerein may be of use for studying phorbol ester receptor isotypes. Induces interleukin-1α and coinducer of interferon with phytohemagglutinin.
1. Slaga, T.J., et al. 1980. Proc. Nat.l Acad. Sci. U.S.A. 77: 3659-3663. PMID: 6774342 2. Christensen, B., et al. 1993. Experientia. 49: 80-83. PMID: 8428615 3. Jaken, S., et al. 1983. Cancer Res. 43: 11-14. PMID: 6600158 4. Lee, W.Y., et al. 1993. Mol. Carcinog. 7: 26-35. PMID: 8435107 5. Jiang, H., et al. 1994. Oncogene. 9: 3397-3406. PMID: 793666 6. Nishio, H., et al. 1994. Gen. Pharmacol. 25: 413-416. PMID: 7926583
Soluble in water (partly), ethanol, and chloroform.
Store at -20° C
1.44 g/cm3 (Predicted)
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Nishio et alNishio et al. (PubMed ID 7926583) found that Mezerein enhanced calcium sequestration via protein kinase C activation in saponized rabbit platelets. -SCBT Publication Review
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