MezereinA PKC activator and second stage tumor promoter

Mezerein (CAS 34807-41-5)

Mezerein | CAS 34807-41-5 is rated 5.0 out of 5 by 1.
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Synonym: 12β-[(E,E)-5-Phenyl-2,4-pentadienoyloxy]daphnetoxin
Application: A PKC activator and second stage tumor promoter
CAS Number: 34807-41-5
Purity: ≥95%
Molecular Weight: 654.70
Molecular Formula: C38H38O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mezerein is a PKC (protein kinase C) activator. Second stage tumor promoter whereas phorbol-12-myristate 13-acetate (PMA) is a first stage tumor promoter. Mezerein may be of use for studying phorbol ester receptor isotypes. Induces interleukin-1α and coinducer of interferon with phytohemagglutinin.


References

1. Slaga, T.J., et al. 1980. Proc. Nat.l Acad. Sci. U.S.A. 77: 3659-3663. PMID: 6774342
2. Christensen, B., et al. 1993. Experientia. 49: 80-83. PMID: 8428615
3. Jaken, S., et al. 1983. Cancer Res. 43: 11-14. PMID: 6600158
4. Lee, W.Y., et al. 1993. Mol. Carcinog. 7: 26-35. PMID: 8435107
5. Jiang, H., et al. 1994. Oncogene. 9: 3397-3406. PMID: 793666
6. Nishio, H., et al. 1994. Gen. Pharmacol. 25: 413-416. PMID: 7926583

Physical State :
Solid
Derived From :
Daphne mezereum
Solubility :
Soluble in water (partly), ethanol, and chloroform.
Storage :
Store at -20° C
Melting Point :
258-262° C
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HB5425500
PubChem CID :
9549167
MDL Number :
MFCD00135953
Beilstein Registry :
1675867
SMILES :
C[C@@H]1[C@H]([C@]2([C@H]3C4[C@]1([C@@H]5C=C(C(=O)[C@]5([C@@H]([C@@]6([C@H]4O6)CO)O)O)C)OC(O3)(O2)C7=CC=CC=C7)C(=C)C)OC(=O)/C=C/C=C/C8=CC=CC=C8

Download SDS (MSDS)

Certificate of Analysis

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Mezerein  Product Citations

See how others have used Mezerein. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26431317  Glover, KP. et al. 2015. PLoS ONE. 10: e0139850.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Nishio et al Nishio et al. (PubMed ID 7926583) found that Mezerein enhanced calcium sequestration via protein kinase C activation in saponized rabbit platelets. -SCBT Publication Review
Date published: 2015-06-23
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