Date published: 2025-9-5

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Methyldiphenylphosphine oxide (CAS 2129-89-7)

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CAS Number:
2129-89-7
Molecular Weight:
216.22
Molecular Formula:
C13H13OP
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyldiphenylphosphine oxide is utilized in applications concerned with its role as a ligand and catalyst in organic synthesis. Methyldiphenylphosphine oxide is in studies of catalytic processes involving the addition of phosphorus groups to organic molecules, which are for developing new methodologies. Methyldiphenylphosphine oxide is also studied for its thermal stability and unique electronic properties, making it an important component in the design of organophosphorus compounds in various chemical reactions. Some explore its utility in the synthesis of complex organic molecules, particularly those that benefit from the introduction of phosphine oxide functionalities to enhance reactivity and selectivity. The compound′s role in facilitating cross-coupling reactions is another significant area of study, helping to broaden the scope of its applications in modern chemistry.


Methyldiphenylphosphine oxide (CAS 2129-89-7) References

  1. Exploiting In Situ Solid-State NMR for the Discovery of New Polymorphs during Crystallization Processes.  |  Hughes, CE., et al. 2012. J Phys Chem Lett. 3: 3176-81. PMID: 26296025
  2. Manganese(I) Catalyzed Alkenylation of Phosphine Oxides Using Alcohols with Liberation of Hydrogen and Water.  |  Pandia, BK., et al. 2021. J Org Chem. 86: 17848-17855. PMID: 34818022
  3. Precisely predicting the 1H and 13C NMR chemical shifts in new types of nerve agents and building spectra database.  |  Jeong, K., et al. 2022. Sci Rep. 12: 20288. PMID: 36434133
  4. The Reaction of Triphenylphosphine Oxide with Alkyllithium and Grignard Reagents  |  Seyferth, D., Welch, D. E., & Heeren, J. K. 1964. Journal of the American Chemical Society. 86(6): 1100-1105.
  5. Phosphorus betaines derived from cycloheptene and cyclooctene oxides. Inversion of cyclooctene  |  Vedejs, E., Snoble, K. A., & Fuchs, P. L. 1973. The Journal of Organic Chemistry. 38(6): 1178-1183.
  6. Lithium diphenylphosphide as a reagent for the dehydroxylation of. alpha.-hydroxy ketones  |  Leone-Bay, A. 1986. The Journal of Organic Chemistry. 51(12): 2378-2379.
  7. The formation of organotin halide adducts with 1, 2-bis (diphenylphosphine oxy) ethane and methyldiphenylphosphine oxide  |  Yoder, C. H., Coley, S. M., Kneizys, S. P., & Spencer, J. N. 1989. Journal of organometallic chemistry. 362(1-2): 59-62.
  8. Self-Assembly of a Macrocyclic Dinuclear Pd (II)–Phosphine Complex  |  Fujita, M., Yazaki, J., Kuramochi, T., & Ogura, K. 1993. Bulletin of the Chemical Society of Japan. 66(6): 1837-1839.
  9. Preparation and reactivity of phenyltelluroalkylphosphine oxides. Vinylic tellurides  |  Silveira, C. C., Braga, A. L., & Guadagnin, R. C. 2003. Tetrahedron letters. 44(30): 5703-5705.
  10. Stereocontrolled synthesis of 3-amino-2-hydroxyalkyl diphenylphosphine oxides mediated by chiral azetidinium salts and epoxyamines  |  Krawiecka, B., & Jeziorna, A. 2005. Tetrahedron letters. 46(25): 4381-4384.
  11. Preparation and properties of flame retardant poly (urethane‐imide) s containing phosphine oxide moiety  |  Özarslan, Ö., Bayazıt, M. K., & Catıker, E. 2009. Journal of applied polymer science. 114(2): 1329-1338.
  12. Switching between halogen-and hydrogen-bonding in stoichiometric variations of a cocrystal of a phosphine oxide  |  Oh, S. Y., Nickels, C. W., Garcia, F., Jones, W., & Friščić, T. 2012. CrystEngComm. 14(19): 6110-6114.
  13. Calculation of the infrared spectra of organophosphorus compounds and prediction of new types of nerve agents  |  Kim, H., Yoon, U. H., Ryu, T. I., Jeong, H. J., il Kim, S., Park, J.,.. & Jeong, K. 2022. New Journal of Chemistry. 46(18): 8653-8661.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyldiphenylphosphine oxide, 5 g

sc-228590
5 g
$51.00