Methotrexate-methyl-d3, Dimethyl Ester CAS: 432545-60-3
MF: C22H23D3N8O5
MW: 485.51
A deuterated esterified folic acid antagonist.

Methotrexate-methyl-d3, Dimethyl Ester (CAS 432545-60-3)

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Alternate Names: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid-d3 Dimethyl Ester
Application: Methotrexate-methyl-d3, Dimethyl Ester is a deuterated esterified folic acid antagonist
CAS Number: 432545-60-3
Molecular Weight: 485.51
Molecular Formula: C22H23D3N8O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Methotrexate-methyl-d3 is a deuterated esterified form of Methotrexate which is an antineoplastic and antirheumatic agent. Studies indicate that Methotrexate-methyl-d3 can act as a folic acid (sc-204758) antagonist. Methotrexate competitively and irreversibly inhibits DHFR (dihydrofolate reductase) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that Methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression..

Physical State :
Solid
Solubility :
Soluble in DMF, DMSO and Methanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[2H]C([2H])([2H])N(CC1=NC2=C(N=C1)N=C(N)N=C2N)C1=CC=C(C=C1)C(=O)NC(CCC(=O)OC)C(=O)OC

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Certificate of Analysis

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