Methimepip dihydrobromide extremely selective histamine H3 receptor agonist [pKi values are 9.0, 5.7, < 5.0 and < 5.0 for Histamine H3 (hH3), Histamine H4 (hH4), Histamine H1(hH1) and Histamine H2(hH2) receptors respectively]. Potently inhibits EFS-evoked contractions of guinea pig ileum (pD2 = 8.26).
Kitbunnadaj et al (2005) N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J.Med.Chem. 48 2100.
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