Met Kinase InhibitorA competitive inhibitor of Met kinase activity

Met Kinase Inhibitor (CAS 658084-23-2)

Met Kinase Inhibitor | CAS 658084-23-2 is rated 5.0 out of 5 by 1.
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Synonym: (3Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide; SU11274
Application: A competitive inhibitor of Met kinase activity
CAS Number: 658084-23-2
Purity: ≥98%
Molecular Weight: 568.1
Molecular Formula: C28H30ClN5O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Met Kinase Inhibitor is a pyrrole indolinone compound acting as an ATP-competitive inhibitor of Met kinase activity. Met Kinase Inhibitor shows great (>60-fold) selectivity over Flk and Ron, FGFR-1, c-Src, Cdk2, PDGFRβ, EGFR, and Tie-2 (>400-fold). Met Kinase Inhibitor demonstrated inhibitory effects on HGF/SF-stimulated cellular signaling and Med-mediated tumorigenisis.


References

Ma. P. C., et al. 2005. Cancer Res. 65, 1479. Berthou, S., et al. 2004. Oncogene 23, 5387. Wang, X., et al. 2003. Mol. Cancer Ther. 2, 1085. Sattler, M., et al. 2003. Cancer Res. 63, 5462.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml) at 60° C, and ethanol (≥2 mg/ml) at 25° C. Insoluble in water.
Storage :
Store at 4° C
IC50 :
Met kinase activity: IC50 = 20 nM; Hepatocyte growth factor receptor: IC50 = 10 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9549297
MDL Number :
MFCD08276928
SMILES :
CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

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Certificate of Analysis

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Met Kinase Inhibitor  Product Citations

See how others have used Met Kinase Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26940070  Yong, X. et al. 2016. Cancer letters. 374: 292-303.

PMID: # 24835851  Lim, YC. et al. 2014. Oral Oncol. 50: 633-9.

PMID: # 22205724  Kindrachuk, J. et al. 2012. Mol. Cell Proteomics. 11: M111.015701.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Yi YW; et al Yi YW; et al. (PubMed ID: 25955731) determined that Met Kinase Inhibitor induced G2 arrest in breast cancer cell line MDA-MB-231. -SCBT Publication Review
Date published: 2015-02-26
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