MeOSuc-AAPV-pNA, Chromogenic Substrate CAS: 70967-90-7
MF: C27H38N6O9
MW: 590.63
A sensitive PR3 and neutrophil elastase chromogenic substrate.

MeOSuc-AAPV-pNA, Chromogenic Substrate (CAS 70967-90-7)

MeOSuc-AAPV-pNA, Chromogenic Substrate | CAS 70967-90-7 is rated 5.0 out of 5 by 1.
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Datasheets

Alternate Names: N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide
Application: MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive PR3 and neutrophil elastase chromogenic substrate
CAS Number: 70967-90-7
Purity: >98%
Molecular Weight: 590.63
Molecular Formula: C27H38N6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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MeOSuc-AAPV-pNA, Chromogenic Substrate is a sensitive chromogenic substrate for PR3 (proteinase 3; PRTN3) and neutrophil elastase. PR3 is a polymorphonuclear leukocyte (PMNL) serine proteinase that degrades a variety of matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV and contributes to the proteolytic generation of antimicrobial peptides. Neutrophil elastase is a serine proteinase that during inflammation, is secreted by neutrophils to destroy bacteria as well as host tissue. Evaluating human and murine PR3 and neutrophil elastase enzymes are helpful to understanding PR3-related and inflammatory autoimmune processes. Researchers have used this product in cystic fibrosis research, as elastin degradation has been reported to increase in cystic fibrosis patients. Hydrolysis or cleavage of this substrate product can be detected at 405-410 nm. This product is not a suitable substrate for cathepsin G nor chymotrypsin.


References

1. Nakajima, K., et al. 1979. J. Biol. Chem. 254: 4027-4032. PMID: 312290
2. Rao, N.V., et al. 1991. J. Biol. Chem. 266: 9540-9548. PMID: 2033050
3. Stone, P.J., et al. 1995. Am. J. Respir. Crit. Care Med. 152: 157-162. PMID: 7599816
4. Hill, D.A., et al. 1999. Toxicol. Sci. 47: 118-125. PMID: 10048160
5. Belaaouaj, A., et al. 2000. Science. 289: 1185-1188. PMID: 10947984
6. Wiesner, O., et al. 2005. FEBS Lett. 579: 5305-5312. PMID: 16182289
7. Greten, F.R., et al. 2007. Cell. 130: 918-931. PMID: 17803913

Physical State :
Solid
Sequence :
N-Methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
Solubility :
Soluble in DMSO (>20 mM), methanol (1 mg/ml), DMF (25 mg/ml), EtOH, and water (0.5 mg/ml).
Storage :
Store at -20° C
Boiling Point :
958.38° C at 760 mmHg
Density :
1.30 g/cm3
Refractive Index :
n20D 1.57
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00077137
Beilstein Registry :
6266359
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](C)C(=O)N1CCC[[email protected]]1C(=O)N[[email protected]@H](C(C)C)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCC(=O)OC

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Certificate of Analysis

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Is this cell permeable?

Asked by: angie
Thank you for your question. The ability of this chemical, MeOSuc-AAPV-pNA, Chromogenic Substrate, to be cell permeable has not been tested.
Answered by: Technical Support
Date published: 2017-04-06
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Rated 5 out of 5 by from Junger Junger, WG. et al. (PubMed 1418684) used MeOSuc-AAPV-pNA, a sensitive PR3 and neutrophil elastase chromogenic substrate, to study the enzymatic and release characteristics of sheep neutrophil elastase compared to human neutrophil elastase. -SCBT Publication Review
Date published: 2015-03-11
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