Melittin, an antibacterial originally derived from Apis mellifera, has been reported to cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4α-Phorbol 12-myristate 13-acetate (sc-202021) induced invasion of proliferative cells via inhibition of activator protein-1 and NF-κB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).
1. Han, S., et al. 2009. J Asian Nat Prod Res. 11: 796-804. PMID: 20183327 2. Park, C., et al. 2010. Biochem. Biophys. Res. Commun. 394: 170-172. PMID: 20188067 3. Park, J.H., et al. 2010. Mol. Cells. 29: 209-215. PMID: 20082219
Just I wanted to ask if the Melittin (CAS 37231-28-0) is obtained from synthesis of from bee venom (by extortion).
Thanks in advance
Asked by: Mseki
Thank you very much for your question. The sc-200868 is derived from chemycal synthesis with the sequence Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2.
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Choi JH; et alChoi JH; et al. (PubMed ID: 26330195) determined that Melittin, the main component in bee venom, could be a promising antimicrobial agent for therapy of MRSA induced wounds. -SCBT Publication Review
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