Date published: 2025-10-13

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Melibiose (CAS 585-99-9)

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Alternate Names:
α-D-Melibiose hydrate
Application:
Melibiose is a carbon substrate
CAS Number:
585-99-9
Molecular Weight:
342.30
Molecular Formula:
C12H22O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Melibiose, a disaccharide composed of glucose and galactose, has garnered significant interest in scientific research across various fields. Its unique properties have made it a subject of investigation for numerous applications. In the realm of microbiology, melibiose has been extensively studied as a carbon source in microbial fermentation processes. Its utilization by microorganisms has shed light on metabolic pathways and enzymatic mechanisms involved in its breakdown and assimilation. Researchers have also explored the potential of melibiose as a carbon substrate for the production of industrially relevant compounds such as biofuels, organic acids, and enzymes. Additionally, melibiose has been utilized in food science research to investigate its impact on food quality and stability. It has been studied for its role in caramelization reactions, Maillard reactions, and as a substrate for enzymatic modification in the development of new food products. Moreover, melibiose has shown promise in the formulation of novel materials. Its incorporation into polymeric systems, including hydrogels and nanoparticles, has been investigated to engineer materials with tailored properties for applications in areas such as drug delivery, tissue engineering, and biodegradable packaging. By unraveling the mechanisms underlying its actions, researchers continue to explore the versatile applications of melibiose, paving the way for further advancements in scientific research.


Melibiose (CAS 585-99-9) References

  1. Melibiose carrier of Escherichia coli: use of cysteine mutagenesis to identify the amino acids on the hydrophilic face of transmembrane helix 2.  |  Matsuzaki, S., et al. 1999. Biochim Biophys Acta. 1420: 63-72. PMID: 10446291
  2. Melibiose transport system in Lactobacillus plantarum.  |  Tamura, C. and Matsushita, O. 1992. Microbiol Immunol. 36: 1119-28. PMID: 1337134
  3. Melibiose, a Nondigestible Disaccharide, Promotes Absorption of Quercetin Glycosides in Rat Small Intestine.  |  Tanaka, S., et al. 2016. J Agric Food Chem. 64: 9335-9341. PMID: 27794607
  4. Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.  |  Chen, CM., et al. 2020. Cells. 9: PMID: 32429337
  5. Lactulose and Melibiose Attenuate MPTP-Induced Parkinson's Disease in Mice by Inhibition of Oxidative Stress, Reduction of Neuroinflammation and Up-Regulation of Autophagy.  |  Lin, CH., et al. 2020. Front Aging Neurosci. 12: 226. PMID: 32848705
  6. The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues.  |  Staniszewska, M., et al. 2021. Sci Rep. 11: 2940. PMID: 33536563
  7. Cooperative binding ensures the obligatory melibiose/Na+ cotransport in MelB.  |  Hariharan, P. and Guan, L. 2021. J Gen Physiol. 153: PMID: 34110360
  8. X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB.  |  Guan, L. and Hariharan, P. 2021. Commun Biol. 4: 931. PMID: 34341464
  9. Complete cysteine-scanning mutagenesis of the Salmonella typhimurium melibiose permease.  |  Markham, KJ., et al. 2021. J Biol Chem. 297: 101090. PMID: 34416232
  10. Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.  |  Wu, Z., et al. 2021. Life (Basel). 11: PMID: 34575099
  11. Substrate-binding guides individual melibiose permeases MelB to structurally soften and to destabilize cytoplasmic middle-loop C3.  |  Blaimschein, N., et al. 2023. Structure. 31: 58-67.e4. PMID: 36525976

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Melibiose, 10 mg

sc-221880
10 mg
$26.00

Melibiose, 5 g

sc-221880A
5 g
$61.00