Melatonin-d4 CAS: 66521-38-8
MF: C13H12D4N2O2
MW: 236.30

Melatonin-d4 (CAS 66521-38-8)

Melatonin-d4 | CAS 66521-38-8 is rated 5.0 out of 5 by 2.
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Alternate Names: Melatonin-d4 is also known as 5-Methoxy-N-acetyltryptamine-d4.
Application: Melatonin-d4 is an antioxidant and indoleamine neurohormone postulated to mediate photoperiodicity in mammals.
CAS Number: 66521-38-8
Molecular Weight: 236.30
Molecular Formula: C13H12D4N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Melatonin-d4 is a hormone postulated to mediate photoperiodicity in mammals. Quantification of melatonin by GC or LC-MS analysis can utilize Melatonin-d4 as an internal standard. Melatonin-d4 inhibits cerebellar nitric oxide synthetase. As a terminal antioxidant, Melatonin-d4 can scavenge free radicals. Melatonin-d4 can also upregulate Glutathione peroxidase, catalase, and superoxide dismutases.


References

1. Boutin, J.A., Audinot, V., Ferry, G., et al.Molecular tools to study melatonin pathways and actions. Trends in Pharamacological Sciences 26(8), 412-419 (2005).
2. Reiter, R.J., Tan, D.X., Manchester, L.C., et al.Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochemistry and Biophysics 34, 237-256 (2001).
3. Reiter, R.J., Tang, L., Garcia, J.J., et al.Pharmacological actions of melatonin in oxygen radical pathophysiology. Life Sciences 60, 2255-2271 (1997).

Physical State :
Solid
Solubility :
Soluble in Chloroform and Methanol
Storage :
Store at -20° C
Melting Point :
117-128° C
Boiling Point :
~512.8° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[2H]C([2H])(C1=CNC2=C1C=C(C=C2)OC)C([2H])([2H])NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Melatonin-d4 (CAS 66521-38-8)  Product Citations

See how others have used Melatonin-d4 (CAS 66521-38-8). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30625588  Lefèvre, A.|Mavel, S.|Nadal-Desbarats, L.|Galineau, L.|Attucci, S.|Dufour, D.|Sokol, H.|Emond, P.| et al. 2019. Talanta. 195: 593-598.

PMID: # 26966272  Reinholds, I. et al. 2016. J Chromatogr Sci. 54: 977-84.

PMID: # 32064655  J. Pineal Res. e12640.

Citations 1 to 3 of 3 total

Dear Sir / Madam, Please could you advise on the delivery timescale for this product: Melatonin-D4, CAS:66521-38-8. Thanks, Mike.

Asked by: MikeD
Thank you for your question. The product is currently in stock. We offer over night shipment to many locations. Please contact our Customer Service department to place a product order or to ask for a sales quotation inlcuding delivery time.
Answered by: Technical Support
Date published: 2018-11-26
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Rated 5 out of 5 by from 不错 11月2日收到的货,发货速度还不错!产品质量也不错!客户反映挺好!官网信息也比较齐全!方便查阅!以后还会购买!
Date published: 2017-11-30
Rated 5 out of 5 by from Kunst et al Kunst et al. (PubMed ID 26393668) found that melatonin-d4 regulated Pgc-1 -induced circadian neurohormone release in the murine retina. -SCBT Publication Review
Date published: 2015-07-13
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