MEHPA bioactive metabolite of DEHP

MEHP (CAS 4376-20-9)

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Synonym: Mono(2-ethylhexyl) Phthalate; 1,2-Benzenedicarboxylic Acid Mono(2-ethylhexyl) Ester; 2-Ethylhexyl Hydrogen Phthalate
Application: A bioactive metabolite of DEHP
CAS Number: 4376-20-9
Molecular Weight: 278.34
Molecular Formula: C16H22O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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MEHP is a bioactive metabolite of DEHP (sc-254975) which inhibits the 17,20 lyase activity of CYP17. MEHP has been shown to modulate the expression of a broad spectrum of genes, including the downregulation of the steroidogenic genes Insl3, expressed in Leydig cells, and Inha, expressed in both Leydig and Sertoli cells during fetal life. It has also been shown to induce apoptosis in germ and Sertoli cells via disruption of junction complexes.

Physical State :
Liquid
Storage :
Store at 4° C
Boiling Point :
408.9° C (Predicted)
Density :
1.1 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
20393
SMILES :
CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)O

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MEHP  Product Citations

See how others have used MEHP. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28184906  Warkus, ELL. et al. 2017. Toxicol. Sci. 157: 235-245.

Citations 1 to 1 of 1 total
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