MEG (sulfate) is a selective scavenger of peroxynitrite and a NOS2 (iNOS) inhibitor. The EC50 values for inhibition of NOS2 (LPS-treated rat lung), NOS3 (eNOS) (bovine endothelial), and NOS1 (nNOS) (rat brain) are 11.5, 110, and 60 μM, respectively. MEG reacts with peroxynitrite with a second order rate constant of 1,900 M-1s-1 at 37°C. MEG (sulfate) also has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of NOS2 and as a scavenger of peroxynitrite.
1 Southan, G.J., Zingarelli, B., O'Connor, M., et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117 619-632 (1996). 2 Szabó, C., Ferrer-Sueta, G., Zingarelli, B., et al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272 9030-9036 (1997). 3 Cuzzocrea, S., Zingarelli, B., Hake, P., et al. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radic Biol Med 24 450-459 (1998).
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.