Medroxyprogesterone 17-AcetateA synthetic progesterone receptor agonist

Medroxyprogesterone 17-Acetate (CAS 71-58-9)

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Synonym: MAP; Clinovir; Depo-Provera; Farlutal; Nidaxin; Oragest; Prodasone; Provera; Veramix
Application: A synthetic progesterone receptor agonist
CAS Number: 71-58-9
Purity: ≥98%
Molecular Weight: 386.52
Molecular Formula: C24H34O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Medroxyprogesterone 17-Acetate is an angiostatic steroid, found to inhibit tumor growth, collagenolysis, vascularization, and plasmin generation. It is a synthetic variant of progesterone, and a potent progesterone receptor (PR) agonist.


1. Blei, F., et al., 1993. Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis. Journal of cellular physiology. 155(3): 568-78. PMID: 7684043

Appearance :
Crystalline powder
Physical State :
Solubility :
Soluble in DMF, ethanol (12 mg/ml at 25° C), methanol (sparingly), DMSO (12 mg/ml at 25° C), and water (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
206-207° C (lit.)
Boiling Point :
~496.4° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20/D +47°, c = 1 in dioxane
IC50 :
Progesterone receptor: IC50 = 2.25 nM (bovine); AR: IC50 = 6.1 nM (human); GR: IC50 = 10 nM (human); Estrogen receptor: IC50 = 0.92 µM (human); MCR: IC50 = 1.20 µM (human)
Ki Data :
Progesterone receptor: Ki= 0.29 nM (bovine); AR: Ki= 2.9 nM (human); GR: Ki= 8.6 nM (human); GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam): Ki= 6.31 µM; Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin): Ki= 13.41 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 5793
MDL Number :
EC Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

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