Meclofenamate sodiumCAS: 6385-02-0
MF: C14H10Cl2NO2•Na
MW: 318.13
An inhibitor of 5-LO, Cox-1, and Cox-2.

Meclofenamate sodium (CAS 6385-02-0)

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Synonym: Meclofenamic acid sodium salt; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
Application: An inhibitor of 5-LO, Cox-1, and Cox-2
CAS Number: 6385-02-0
Purity: ≥98%
Molecular Weight: 318.13
Molecular Formula: C14H10Cl2NO2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Meclofenamate sodium is a dual inhibitor of the 5-LO (5-lipoxygenase) and Cox (cyclooxygenase) pathways. Meclofenamate sodium is demonstrated to inhibit both Cox-1 and Cox-2, showing micromolar inhibition of human recombinant hCox-1 (IC50 of 1.5 μM) and hCox-2 (IC50 of 9.7 μM). An irreversible time-dependent inhibition of hCOX-2 is described, involving a rapid equilibrium binding of enzyme and inhibitor followed by formation of a tightly bound inhibited complex.


References

1. Rampart, M.,etal. 1986. Biochem. Pharmacol. 35: 581-586. PMID: 3081008
2. Boctor, A.M., et al. 1986. Prostaglandins Leukot Med. 23: 229-238. PMID: 3020588
3. Laneuville, O., et al. 1994. J. Pharmacol. Exp. Ther. 271: 927-934. PMID: 7965814
4. Ouellet, M. and Percival, M.D. 1995. Biochem. J. 306: 247-251. PMID: 7864817
5. Narsinghani, T., et al. 2006. Bioorg. Med. Chem. Lett. 16: 461-468. PMID: 16290292

Physical State :
Solid
Solubility :
Soluble in water (15 mg/ml), ethanol (100 mg/ml), DMSO (75 mg/ml), and DMF (39 mg/ml).
Storage :
Store at room temperature
Melting Point :
289-291° C
Boiling Point :
399.4° C at 760 mmHg
IC50 :
Dual 5-lipoxygenase: IC50 = 46.8 µM; cyclooxygenase I: IC50 = 0.6 µM; cyclooxygenase II: IC50 = 0.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB2975500
PubChem CID :
4038
Merck Index :
14: 5779
MDL Number :
MFCD00077376
EC Number :
228-983-3
SMILES :
CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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