MDL-12,330A dot HClAn A cyclase inhibitor

MDL-12,330A • HCl (CAS 40297-09-4)

MDL-12,330A andbull HCl | CAS 40297-09-4 is rated 5.0 out of 5 by 1.
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Synonym: cis-N-(2-Phenylcyclopentyl)-azacyclotridec-1-en-2-amine hydrochloride
Application: An A cyclase inhibitor
CAS Number: 40297-09-4
Purity: ≥98%
Molecular Weight: 377.01
Molecular Formula: C23H36N2 HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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MDL-12,330A • HCl is the hydrochloride salt preparation of MDL-12,330A, an inhibitor of A cyclase, PDE (cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases). MDL-12,330A is described to block K+-stimulated and histamine-stimulated cAMP formation. Inhibition of cAMP activity by MDL-12,330A has been employed to identify cAMP-mediated activity in myocardial inotropic functioning and in the regulation of nicotinic cholinergic synapses.


References

1. Hunt, N.H., et al. 1980. Biochim. Biophys. Acta. 613: 499-506. PMID: 6256001
2. Grupp, G., et al. 1980. Br. J. Pharmacol. 70: 429-442. PMID: 6254599
3. Silinsky, E.M. and Vogel, S.M. 1986. Br. J. Pharmacol. 88: 799-805. PMID: 3017493
4. Lippe, C., et al. 1991. Comp. Biochem. Physiol. C. 99: 209-211. PMID: 1711430
5. Correia-de-Sá, P., et al. 1994. Eur. J. Pharmacol. 271: 349-355. PMID: 7705435
6. Alonso-Gómez, A.L., et al. 1995. J. Neurochem. 65: 1054-1060. PMID: 7543927
7. Azuma, M., et al. 2009. Peptides. 30: 1260-1266. PMID: 19540424

Physical State :
Solid
Solubility :
Soluble in water (3 mg/ml), DMSO(slightly warm) (10 mg/ml), ethanol (>10 mg/ml), and hot 0.1N HCl (0.5 mg/ml). Insoluble in 0.1N NaOH.
Storage :
Store at -20° C
Melting Point :
148-152° C
IC50 :
Adenylate cyclase: IC50 = 250 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6917816
MDL Number :
MFCD00210204
SMILES :
C1CCCCCC(=NCCCCC1)NC2CCCC2C3=CC=CC=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

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MDL-12,330A dot HCl  Product Citations

See how others have used MDL-12,330A dot HCl. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 24091307  Bitterman, JL. et al. 2013. J. Pharmacol. Exp. Ther. 347: 589-98.

PMID: # 24843552  McIntosh, CH. et al. 2012. J Diabetes Investig. 3: 96-106.

PMID: # 20068138  Arakawa, M. et al. 2010. Diabetes. 59: 1030-1037.

PMID: # 19540424  Azuma, M. et al. 2009. Peptides. 30: 1260-1266.

PMID: # 7543927  Alonso-Gómez, AL. et al. 1995. J. Neurochem. 65: 1054-1060.

PMID: # 7705435  Correia-de-Sá, P. et al. 1994. Eur. J. Pharmacol. 271: 349-355.

PMID: # 1711430  Lippe, C. et al. 1991. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. 99: 209-211.

Citations 1 to 7 of 7 total

MDL-12,330A hydrochloride, what is its pKa

Asked by: darszon
Thank you for your question. Unfortunately due to the variable nature we are unable to provide the pKa data for this compound. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Technical Service
Date published: 2017-07-13
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Rated 5 out of 5 by from Winston AB; et al Winston AB; et al. (PubMed ID: 26311996) determined that MDL-12,330A HCL, a cyclase inhibitor, still allowed 10 M sildenafil to inhibit KCl-induced myometrial contractility.] -SCBT Publication Review
Date published: 2015-04-28
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