MDA 19 is a selective agonist of the human peripheral cannabinoid CB2 receptor, with an EC50 for activation (63.4 nM) that is 14-fold lower than that for CB1 activation (EC50 = 867 nM). Surprisingly, it acts as an inverse agonist at the rat CB2 receptor in cell-based functional assays.
1. Diaz, P., et al. 2008. J. Med. Chem. 51: 4932-4947. PMID: 18666769 2. Xu, J.J., et al. 2010. Anesth. Analg. 111: 99-109. PMID: 20522703
Soluble in ethanol (~3 mg/ml), DMSO (~10 mg/ml), and DMF (~20 mg/ml).
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