Anti-MASP-1/3 Antibody (F-12) is a mouse monoclonal IgG2a κ MASP-1/3 antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 171-430 mapping within an internal region of MASP-1 of human origin
Anti-MASP-1/3 Antibody (F-12) is recommended for detection of MASP-1/3 heavy chain of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-MASP-1/3 Antibody (F-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MASP-1/3 (F-12): sc-166815.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for MASP-1/3 Antibody (F-12) for WB applications. These reagents are now offered in bundles with MASP-1/3 Antibody (F-12) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
MASP-1/3 Antibody (F-12) is a high quality monoclonal MASP-1/3 antibody (also designated MASP-1/3 antibody) suitable for the detection of the MASP-1/3 protein of mouse, rat and human origin. MASP-1/3 Antibody (F-12) is available as both the non-conjugated anti-MASP-1/3 antibody form, as well as multiple conjugated forms of anti-MASP-1/3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chains are identical between MASP-1 and MASP-3 but the light/B chains are entirely different. Activated MASPs subsequently cleave and activate downstream components of the complement pathway.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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