Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species with potent anthelmintic activity. The marcfortines are structurally related to paraherquamides and thought to act by blockade of cholinergic neuromuscular transmission.
1. Further novel metabolites of the paraherquamide family. Blanchflower S.E. et al. J. Antibiot. 1993, 46, 1355. 2. Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals. Zinser E.W. et al. J. Vet. Pharmacol. Ther. 2002, 25, 241. 3. Aspergillicins A-E: five novel depsipeptides from the marine-derived fungus Aspergillus carneus. Capon R.J. et al. Org. Biomol. Chem. 2003, 1, 1856.
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PMID: # 27707355 Dagnac, T. et al. 2016. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
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