Marbofloxacin (CAS 115550-35-1)

Marbofloxacin, identified with the CAS number 115550-35-1, is a synthetic fluoroquinolone compound extensively utilized in microbiological research to study the dynamics of bacterial DNA replication and cell division processes. The principal mechanism of action of Marbofloxacin involves the inhibition of bacterial DNA gyrase and topoisomerase IV. These critical enzymes are responsible for maintaining the supercoiling state of DNA, which is essential for proper DNA replication and segregation during cell division. By binding to these enzymes, Marbofloxacin introduces breaks in the bacterial DNA, prevents the resealing of these breaks, and thus disrupts the replication process, leading to an inhibition of bacterial growth and multiplication. This specific interaction makes Marbofloxacin a valuable tool in research focused on understanding the intricacies of bacterial DNA manipulation and the effects of enzyme inhibition on bacterial viability. Studies using Marbofloxacin have explored its efficacy against a broad spectrum of bacteria, providing insights into the mechanisms of action of fluoroquinolones and the development of resistance. Furthermore, research involving Marbofloxacin has also helped to explain the role of mutation rates in bacterial populations under antibiotic pressure, contributing significantly to the field of microbial genetics and antibiotic resistance studies.