Maprotiline Hydrochloride CAS: 10347-81-6
MF: C20H23N•HCl
MW: 313.87
A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons.

Maprotiline Hydrochloride (CAS 10347-81-6)

Maprotiline Hydrochloride | CAS 10347-81-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Ludiomil; Psymion
Application: Maprotiline Hydrochloride is A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons
CAS Number: 10347-81-6
Purity: ≥98%
Molecular Weight: 313.87
Molecular Formula: C20H23N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Maprotiline Hydrochloride is an inhibitor of norepinephrine reuptake. It acts primarily by potentiation of central adrenergic (AR) synapses by blocking reuptake of norepinephrine at nerve endings. Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.


References

1. Yamaguchi, M., et al. 1999. Anal. Biochem. 270: 296-302. PMID: 10334847
2. Mochizucki, D. 2004. Hum. Psychopharmacol. 19: S15-19. PMID: 15378668
3. Mayers, A.G., et al. 2005. Hum. Psychopharmacol. 20: 533-559. PMID: 16229049
4. Tang, T.S., et al. 2005. Proc. Natl. Acad. Sci. U.S.A. 102: 2602-2607. PMID: 15695335

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), and ethanol (10 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.60
IC50 :
PhoP regulon: IC50 = 53.52 µM (Salmonella typhi)
pK Values :
pKb: 10.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KJ4555000
PubChem CID :
Merck Index :
14: 5748
MDL Number :
MFCD00079464
EC Number :
233-758-8
SMILES :
CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl

Download SDS (MSDS)

Certificate of Analysis

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Maprotiline Hydrochloride (CAS 10347-81-6)  Product Citations

See how others have used Maprotiline Hydrochloride (CAS 10347-81-6). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 34112854  Sijben, HJ.|van Oostveen, WM.|Hartog, PBR.|Stucchi, L.|Rossignoli, A.|Maresca, G.|Scarabottolo, L.|IJzerman, AP.|Heitman, LH.| et al. 2021. Sci Rep. 11: 12290.

PMID: # 27433579  Silva, EL.|Lima, FA.|Carneiro, G.|Ramos Jonas Periera, .|Gomes, DA.|de Souza-Fagundes, EM.|Ferreira, LA.| et al. 2016. J Nanosci Nanotechnol. 16: 1291-300.

PMID: # 15236632  Hsu, SS. et al. 2004. Clin. Exp. Pharmacol. Physiol. 31: 444-449.

PMID: # 7581917  Ishida, J. et al. 1995. J. Chromatogr. B, Biomed. Appl. 669: 390-396.

PMID: # 1852793  de Jonghe, F. et al. 1991. Pharmacopsychiatry. 24: 62-67.

PMID: # 31927466  Colloids Surf B Biointerfaces. 188: 110749.

PMID: # 32681288  Pharm. Res. 148.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Gurgel Gurgel, JA. et al. (PubMed 24402214) reported that Amitriptyline, Clomipramine, and Maprotiline attenuate the inflammatory response by inhibiting neutrophil migration and mast cell degranulation. -SCBT Publication Review
Date published: 2015-07-03
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