MAP4A selective group III mGluR (metabotropic glutamate receptor) agonist

MAP4 (CAS 157381-42-5)

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Synonym: (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Application: A selective group III mGluR (metabotropic glutamate receptor) agonist
CAS Number: 157381-42-5
Molecular Weight: 197.1
Molecular Formula: C5H12NO5P
* Refer to Certificate of Analysis for lot specific data (including water content).
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MAP4 is a selective antagonist for group III mGluRs. Group III (mGluR-4, mGluR-6, mGluR-7, and mGluR-8) metabotropic glutamate receptors are coupled to Gi/0 which in turn inhibits adenylyl cyclase, decreasing the formation of cAMP.


References

1. Jane, D.E., et al. 1994. Br. J. Pharmacol. 112: 809-816. PMID: 7921606
2. Watkins, J., et al. 1994. Trends Pharmacol Sci. 15: 333-342. PMID: 7992387
3. Knöpfel, T., et al. 1995. Neuropharmacology. 34: 1099-1102. PMID: 8532159
4. Salt, T.E. and Eaton, S.A. 1995. Neuroscience. 65: 5-13. PMID: 7753406
5. Gomeza, J., et al. 1996. Mol. Pharmacol. 50: 923-930. PMID: 8863838
6. Kemp, M.C., et al. 1996. Eur. J. Pharmacol. 309: 79-85. PMID: 8864697
7. Sekiyama, N., et al. 1996. Br. J. Pharmacol. 117: 1493-1503. PMID: 8730745
8. Faden, A.I., et al. 1997.J. Neurotrauma 14: 885-895. PMID: 9475370

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), and dilute aqueous base.
Storage :
Store at 4° C
Melting Point :
248.92° C (Predicted)
Boiling Point :
472.05° C at 760 mmHg (Predicted)
Density :
1.53 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20/D +11.6°, c = 1 in 6N HCl
pK Values :
pKa: 2.09 (Predicted), pKb: 9.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1795545
MDL Number :
MFCD00672650
SMILES :
CC(CCP(=O)([O-])[O-])(C(=O)[O-])[NH3+]

Download SDS (MSDS)

Certificate of Analysis

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