Mafosfamide Sodium SaltA cyclophosphamide analog that induces apoptosis and acts as an antitumor agent in vitro

Mafosfamide Sodium Salt (CAS 84211-05-2)

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Synonym: cis-Mafosfamide Sodium
Application: A cyclophosphamide analog that induces apoptosis and acts as an antitumor agent in vitro
CAS Number: 84211-05-2
Purity: ≥95%
Molecular Weight: 423.25
Molecular Formula: C9H18Cl2N2O5PS2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mafosfamide Sodium Salt is a cyclophosphamide (sc-361165) analog which induces apoptosis in lymphoblastoid cells. It also acts as an antitumor agent in vitro.


References

1. Miller, CR. et al. 2017. Oncotarget. 8: 25942-25954. PMID: # 28412730

2. Ninomiya, S. et al. 2015. Blood. 125: 3905-16. PMID: # 25940712

3. Klaus, CR. et al. 2014. The Journal of pharmacology and experimental therapeutics. 350: 646-56. PMID: # 24993360

4. Knutson, SK. et al. 2014. PloS one. 9: e111840. PMID: # 25493630

5. Kikuchi, K. et al. 2014. PLoS genetics. 10: e1004107. PMID: # 24453992

6. Burgess, M. et al. 2013. Clinical cancer research : an official journal of the American Association for Cancer Research. 19: 5675-85. PMID: # 23948971

Usage :
Chemical is very hygroscopic and can be stored as supplied for a year at -20° C under inert atmosphere before retesting is recommended.
Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
76-80° C
Refractive Index :
n20D 1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71749874
SMILES :
C1CO[P@](=O)(N[C@@H]1SCCS(=O)(=O)[O-])N(CCCl)CCCl.[Na+]

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Certificate of Analysis

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Mafosfamide Sodium Salt  Product Citations

See how others have used Mafosfamide Sodium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 31336593  Devin, J.|Kassambara, A.|Bruyer, A.|Moreaux, J.|Bret, C.| et al. 2019. J Clin Med. 8:

PMID: # 29920526  Moreno, MJ.|Gallardo, A.|Novelli, S.|Mozos, A.|Aragó, M.|Pavón, MÁ.|Céspedes, MV.|Pallarès, V.|Falgàs, A.|Alcoceba, M.|Blanco, O.|Gonzalez-Díaz, M.|Sierra, J.|Mangues, R.|Casanova, I.| et al. 2018. PLoS ONE. 13: e0198789.

PMID: # 28412730  Miller, CR. et al. 2017. Oncotarget. 8: 25942-25954.

PMID: # 28364003  Frazier, JP.|Bertout, JA.|Kerwin, WS.|Moreno-Gonzalez, A.|Casalini, JR.|Grenley, MO.|Beirne, E.|Watts, KL.|Keener, A.|Thirstrup, DJ.|Tretyak, I.|Ditzler, SH.|Tripp, CD.|Choy, K.|Gillings, S.|Breit, MN.|Meleo, KA.|Rizzo, V.|Herrera, CL.|Perry, JA.|Amaravadi, RK.|Olson, JM.|Klinghoffer, RA.| et al. 2017. Cancer Res. 77: 2869-2880.

PMID: # 25940712  Ninomiya, S. et al. 2015. Blood. 125: 3905-16.

PMID: # 24993360  Klaus, CR. et al. 2014. The Journal of pharmacology and experimental therapeutics. 350: 646-56.

PMID: # 25493630  Knutson, SK. et al. 2014. PloS one. 9: e111840.

PMID: # 24453992  Kikuchi, K. et al. 2014. PLoS genetics. 10: e1004107.

PMID: # 23948971  Burgess, M. et al. 2013. Clinical cancer research : an official journal of the American Association for Cancer Research. 19: 5675-85.

Citations 1 to 9 of 9 total

What concentration does mafosfamide dissolve in DMSO

Asked by: sra758
It has good solubility in DMSO and Methanol, >2 mg/mL.
Answered by: Technical Support
Date published: 2019-09-11

How long can Mafosfamide Sodium Salt (CAS 84211-05-2) be stored once is dissolved in DMSO?

Asked by: SCM4
It is recommended to use the solution the same day it was made. For short term storage of Mafosfamide Sodium Salt solution, however, aliquot into usable amounts and freeze. Multiple freeze/thaw cycles should be avoided. The shelf life has not been determined, but typically solutions should be used with 3-6 months.
Answered by: Tech Service 11
Date published: 2017-03-17
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