Madecassic acidA triterpene immunomodulator and inflammatory agent

Madecassic acid (CAS 18449-41-7)

Madecassic acid | CAS 18449-41-7 is rated 5.0 out of 5 by 1.
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Synonym: Brahmic acid
Application: A triterpene immunomodulator and inflammatory agent
CAS Number: 18449-41-7
Purity: ≥95%
Molecular Weight: 504.70
Molecular Formula: C30H48O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Madecassic acid has been investigated for stimulating collagen synthesis. Madecassic acid acts as a downregulator of NF-kappaB activation in RAW 264.7 macrophage cells which inhibits iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 and results in a reduction in inflammation.


References

1. Maquart, F.X. et al. 1990. Connect. Tissue Res. 24(2): 107-120. PMID: 2354631

2. Bonte, F. et al. 1994. Planta Med. 60(2): 133-135. PMID: 8202564

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at 4° C
Melting Point :
255-260° C
Boiling Point :
641.7° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20D +29.31°, c = 1.01 in methanol
IC50 :
PTP1B: IC50 = 12.38 µM (human); TC-PTP: IC50>20 µM (human); Rhodopsin: EC5050 = 0.12 mM (bovine); Rhodopsin: IC50 = 0.18 mM (bovine)
pK Values :
pKa: 4.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
73412
MDL Number :
MFCD00895441
SMILES :
C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Xia B; et al Xia B; et al. (PubMed ID: 25685908) utilized Madecassic acid to determine that zebrafish possessed strong metabolic capacity for drug discovery research. -SCBT Publication Review
Date published: 2015-03-06
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