Maculosin CAS: 4549-02-4
MF: C14H16N2O3
MW: 260.29
A secondary metabolite of fungi and bacteria.

Maculosin (CAS 4549-02-4)

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Alternate Names: Cyclo-(Pro-Tyr)
Application: Maculosin is a secondary metabolite of fungi and bacteria
CAS Number: 4549-02-4
Molecular Weight: 260.29
Molecular Formula: C14H16N2O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Maculosin is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, maculosin is capable of activating N-acylhomoserine lactones (AHLs). Maculosin is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of maculosin is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Maculosin was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.


References

Graz, C. J. M., et al. J. Pharm. Pharmacol. 52, 75, (2000)

Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in ethanol, methanol, DMSO, DMF. Limited water solubility.
Storage :
Store at -20° C
IC50 :
Spodoptera exigua: IC50 = 37.71 µM; Phenol oxidase: IC50 = 42.48 µM
pK Values :
pKa: 9.92 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
MDL Number :
MFCD03093467

Download SDS (MSDS)

Certificate of Analysis

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