Western blot analysis of Ac-Histone H4 acetylation in untreated (A)...

Western blot analysis of Histone H2B acetylation in untreated (A)...

Western blot analysis of Histone H3 expression in untreated (A)...

Western blot analysis of Histone H3 acetylation in untreated (A)...

Western blot analysis of Histone H2B expression in untreated (A)...

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M 344 (CAS 251456-60-7)

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Application: A potent HDAC inhibitor with IC₅₀ of 100 nM

CAS Number: 251456-60-7

Purity: ≥98%

Molecular Weight: 307.39

Molecular Formula: C₁₆H₂₅N₃O₃

* Refer to Certificate of Analysis for lot specific data (including water content).

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M344 is a potent HDAC inhibitor (IC₅₀ = 100 nM), with selectivity for HDAC6 over HDAC1. M344 induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. It also induces cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells.

References

1. Jung, M., et al., 1999. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. Journal of medicinal chemistry. 42(22): 4669-79. PMID: 10579829

Appearance :

Crystalline

Physical State :

Solid

Solubility :

Soluble in DMSO (62 mg/ml at 25° C), ethanol (4 mg/ml), DMF (~25 mg/ml at 25° C), and water (<1 mg/ml at 25° C).

Storage :

Store at 4° C

Melting Point :

239.82° C (Predicted)

Boiling Point :

558.27° C (Predicted)

Density :

~1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.56 (Predicted)

IC50 :

HDAC1: IC₅₀ = 46 nM (human); HDAC: IC₅₀ = 46 nM (rat); Histone deacetylase HD2: IC₅₀ = 100 nM (Maize (Zea mays)); HDAC1: IC₅₀ = 240 nM (rat); HCT-116: IC₅₀ = 200 µM (human)

pK Values :

pK_a: 9.48 (Predicted), pK_b: 2.92 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

PubChem CID :

3994

MDL Number :

MFCD03453554

SMILES :

CN(C)C1=CC=C(C=C1)C(=O)NCCCCCCC(=O)NO

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Certificate of Analysis

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M 344 Product Citations

See how others have used M 344. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 17230517 Furchert, SE. et al. 2007. Int. J. Cancer. 120: 1787-1794.

PMID: # 16041839 Schäfer, S. et al. 2005. Arch. Pharm. (Weinheim). 338: 347-357.

PMID: # 16262446 Hazzalin, CA. et al. 2005. PLoS Biol. 3: -.

PMID: # 12920038 Cao, H. et al. 2004. Blood. 103: 701-709.

PMID: # 15161353 Zhang, Y. et al. 2004. Radiat. Res. 161: 667-674.

PMID: # 14523559 Kyrylenko, S. et al. 2003. Cell. Mol. Life Sci. 60: 1990-1997.

PMID: # 12817474 Klan, N. et al. 2003. Biol. Chem. 384: 777-785.

PMID: # 19172156 Wang, L. et al. 2009 Mar-Apr. Immunol. Cell Biol. 87: 195-202.

Citations 1 to 8 of 8 total

Rated 5 out of 5 by SM from An increase in Ac An increase in Ac-Histone H4 protein expression was observed by WB when comparing M 344 treated NIH/3T3 cells with those that have not been treated. -SCBT QC

Date published: 2015-03-21

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M 344 (CAS 251456-60-7)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

M 344 Product Citations

M 344 (CAS 251456-60-7)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

M 344 Product Citations

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