Lysophosphatidic AcidA ligand activator for EDG-2, EDG-4, and EDG-7
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Lysophosphatidic Acid (CAS 325465-93-8)

Lysophosphatidic Acid | CAS 325465-93-8 is rated 5.0 out of 5 by 2.
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See product citations (21)
Synonym: 1-oleoyl-sn-glycero-3-phosphate sodium salt; Oleoyl-L-α-lysophosphatidic acid sodium salt; LPA sodium salt
Application: A ligand activator for EDG-2, EDG-4, and EDG-7
CAS Number: 325465-93-8
Purity: ≥98%
Molecular Weight: 458.50
Molecular Formula: C21H40O7P•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lysophosphatidic acid (LPA) is an endogenous glycerophospholipid signaling molecule and ligand activator for EDG-2 and EDG-4 (LPA) receptors. Signaling associated with LPA has been reported to stimulate growth of fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. LPA has been indicated as both a proliferative and anti-apoptotic factor, signaling for Pl3K-mediated regulation of cell activity. LPA has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C.


References

1. Moolenaar, W H., et al., 1995. Lysophosphatidic acid, a multifunctional phospholipid messenger. The Journal of biological chemistry. 270(22): 12949-52. PMID: 7768880

2. Levine, J S., et al., 1997. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. The American journal of physiology. 273(4 Pt 2): F575-85. PMID: 9362335

3. Nishizaki, T., et al., 1997. Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. Brain research. Molecular brain research. 50(1-2): 121-6. PMID: 9406926

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, hygroscopic, protect from light, air sensitive.
Physical State :
Solid
Solubility :
Soluble in chloroform, methanol, acetic acid (10 mg/mL), water (5 mg/mL, with sonication), and DMSO (0.5 mg/mL, warm).
Storage :
Store at -20° C
Refractive Index :
n20D 1.49
IC50 :
Autotaxin: IC50 = 442 nM (human); Lysophosphatidic acid receptor Edg-4: EC5050 = 6.8 nM (human); Lysophosphatidic acid receptor 5: EC5050 = 12 nM (human)
pK Values :
pKa: 1.82
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23688917
MDL Number :
MFCD00133427
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)OCC(COP(=O)(O)[O-])O.[Na+]

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Certificate of Analysis

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Lysophosphatidic Acid  Product Citations

See how others have used Lysophosphatidic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 21 total

PMID: # 30840161  Olianas, MC.|Dedoni, S.|Onali, P.| et al. 2019. Apoptosis.

PMID: # 31145906  Xu, L.|Su, J.|Guo, L.|Wang, S.|Deng, X.|Ma, S.| et al. 2019. Neuropharmacology. 155: 150-161.

PMID: # 31010479  Jobst-Schwan, T.|Hoogstraten, CA.|Kolvenbach, CM.|Schmidt, JM.|Kolb, A.|Eddy, K.|Schneider, R.|Ashraf, S.|Widmeier, E.|Majmundar, AJ.|Hildebrandt, F.| et al. 2019. Kidney Int. 95: 1079-1090.

PMID: # 29474739  Li, W.|Deng, Y.|Feng, B.|Mak, KK.| et al. 2018. J. Bone Miner. Res. 33: 1183-1195.

PMID: # 27754741  Handa, H.|Hashimoto, A.|Hashimoto, S.|Sabe, H.| et al. 2018. Small GTPases. 9: 420-426.

PMID: # 30385786  Deng, Y.|Lu, J.|Li, W.|Wu, A.|Zhang, X.|Tong, W.|Ho, KK.|Qin, L.|Song, H.|Mak, KK.| et al. 2018. Nat Commun. 9: 4564.

PMID: # 29259017  Sun, Z.|Schwenzer, A.|Rupp, T.|Murdamoothoo, D.|Vegliante, R.|Lefebvre, O.|Klein, A.|Hussenet, T.|Orend, G.| et al. 2018. Cancer Res. 78: 950-961.

PMID: # 27447747  Liu, X.|Wang, A.|Liang, X.|Liu, J.|Zou, F.|Chen, C.|Zhao, Z.|Deng, Y.|Wu, H.|Qi, Z.|Wang, B.|Wang, L.|Liu, F.|Xu, Y.|Wang, W.|Fernandes, SM.|Stone, RM.|Galinsky, IA.|Brown, JR.|Loh, T.|Griffin, JD.|Zhang, S.|Weisberg, EL.|Zhang, X.|Liu, J.|Liu, Q.| et al. 2016. Oncotarget. 7: 53515-53525.

PMID: # 27918822  Muralidharan, AR.|Maddala, R.|Skiba, NP.|Rao, PV.| et al. 2016. Invest. Ophthalmol. Vis. Sci. 57: 6482-6495.

PMID: # 27161398  Kumar, A. et al. 2016. J. Cell Biol. 213: 371-83.

Citations 1 to 10 of 21 total

Is it Human Lysophosphatidic acid (LPA) ?

Asked by: microscopy
No, this is synthetic.
Answered by: Technical Support
Date published: 2019-04-13

Is this product  (sc-201053) easy to attach the Eppendorf tube well? If yes, should this product must be stored in siliconized Eppendorf tubes? 

Asked by: Researchers
Thank you for your question. Unfortunately we do not have that information, but the product should be fine if stored at -20ºC. If you have any further questions, please contact our Asia Technical Service team. You can reach us by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-12-03

should this product (sc-201053) be protected from light?

Asked by: Tiewei Li
Thank you for your question. Yes, this product is light sensitive and should be protected from light. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-12-03

Is this an animal-free product? What is the native source?

Asked by: Chemsynth123
Thank you for your question. Lysophosphatidic Acid (CAS 325465-93-8) is an animal-free product and is derived from a synthetic source.
Answered by: Technical Support
Date published: 2017-02-28

Solubility in PBS?

Asked by: chemicalsmg
Thank you for your question. Lysophosphatidic Acid, sc-201053, is soluble in PBS at approximately 8.3 mg/ml with a Ph of 7.2.
Answered by: TechService7
Date published: 2017-03-06

Which solvent do you suggest?

Asked by: Heinzstein
Thank you for your question. This chemical, Lysophosphatidic Acid, sc-201053, is soluble in chloroform, methanol, acetic acid (10mg/ml), water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com, if you have any further questions.
Answered by: Tech Service
Date published: 2016-11-23
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Rated 5 out of 5 by from Works well in my experiment Works well in my experiment, will order again.
Date published: 2015-12-16
Rated 5 out of 5 by from Kollert Kollert, S. et al. (PubMed 26224542) found that excitation of nociceptive neurons by Lysophosphatidic Acid, an endogenous glycerophospholipid signaling molecule, is balanced by co-activation of TRESK channels. This indicates that excitation of sensory neurons in strongly controlled by the activity of TRESK channels. -SCBT Publication Review
Date published: 2015-06-23
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