LY293111

LY293111 (CAS 161172-51-6)

LY293111 | CAS 161172-51-6 is rated 5.0 out of 5 by 1.
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Synonym: VML 295; Etalocib
Application: A BLT1 antagonist
CAS Number: 161172-51-6
Molecular Weight: 544.61
Molecular Formula: C33H33FO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

LY293111 is a potent antagonist of leukotrine B4 repector (BLT1) which inhibits the specific binding of radiolabeled-LTB4 to this receptor (IC50 = 17.6 nM). This further prevents LTB4-induced chemotaxis of neutrophils (IC50 = 6.3 nM). Additional in vitro studies have shown that LY293111 inhibits growth of MiaPaCa-2 and AsPC-1 cell lines and subcutaneous xenografts by inducing apoptosis and S-phase arrest.


References

1. Jackson, W T., et al., 1999. Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies. The Journal of pharmacology and experimental therapeutics. 288(1): 286-94. PMID: 9862783
2. Tong, Wei-Gang., et al., 2002. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 8(10): 3232-42. PMID: 12374694

Formulation :
A solution in methyl acetate
Appearance :
Solution
Physical State :
Liquid
Solubility :
Soluble in water, ethanol, DMF and DMSO
Storage :
Store at -20° C
Boiling Point :
57° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
177941
SMILES :
CCCC1=C(C=CC=C1OCCCOC2=C(C=C(C(=C2)O)C3=CC=C(C=C3)F)CC)OC4=CC=CC=C4C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Tong et al Tong et al. (PubMed ID 12374694) found that the leukotriene B4 receptor antagonist LY293111 inhibited human pancreatic cell growth and induced apoptosis. -SCBT Publication Review
Date published: 2015-04-11
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