LY2603618 (IC-83) is a very selective checkpoint kinase 1 (Chk1) inhibitor with the potential for antitumor effects. Chk1 is an ATP-dependent serine-threonine kinase that is very important to the checkpoint monitoring system of DNA replication.
Soluble in water (<1 mg/ml) at 25 °C, DMSO (13 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.
Store at -20° C
242.28° C (Predicted)
503.11° C at 760 mmHg (Predicted)
1.46 g/cm3 (Predicted)
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Wang et alWang et al. (PubMed ID 24928205) found that the Chk1 protein kinase inhibitor, LY2603618, caused cell cycle arrest at the G2/M phase by preventing Chk1 autophosphorylation and also increased DNA damage-mediated Chk1 phosphorylation in human lung cancer cells. -SCBT Publication Review
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