LY2603618A selective Chk1 inhibitor

LY2603618 (CAS 911222-45-2)

LY2603618 | CAS 911222-45-2 is rated 5.0 out of 5 by 1.
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Synonym: (S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea
Application: A selective Chk1 inhibitor
CAS Number: 911222-45-2
Purity: ≥98%
Molecular Weight: 436.30
Molecular Formula: C18H22BrN5O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY2603618 (IC-83) is a very selective checkpoint kinase 1 (Chk1) inhibitor with the potential for antitumor effects. Chk1 is an ATP-dependent serine-threonine kinase that is very important to the checkpoint monitoring system of DNA replication.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml) at 25 °C, DMSO (13 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.
Storage :
Store at -20° C
Melting Point :
242.28° C (Predicted)
Boiling Point :
503.11° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11955855
SMILES :
CC1=CC(=C(C=C1Br)NC(=O)NC2=NC=C(N=C2)C)OC[C@@H]3CNCCO3

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Certificate of Analysis

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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 24928205) found that the Chk1 protein kinase inhibitor, LY2603618, caused cell cycle arrest at the G2/M phase by preventing Chk1 autophosphorylation and also increased DNA damage-mediated Chk1 phosphorylation in human lung cancer cells. -SCBT Publication Review
Date published: 2015-06-01
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