LY 83583 is a quinolinedione that inhibits soluble guanylate cyclase (GCS). Inhibition of GCS has been reported to lower levels of cGMP and cAMP in rat studies. LY 83583 has been shown to inhibit leukotriene synthesis in guinea-pig lung and rat peritoneal cells in vitro, block the release of endothelium-derived relaxing factor, and enhance glucose transporter-1-mediated glucose transport. Kinetic studies have reported that LY 83583 acts as a competitive inhibitor with respect to NADPH (Ki=2.257 μM). LY 83583 is an inhibitor of glutathione reductase.
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See how others have used LY 83583. Click on the entry to view the PubMed entry .
PMID: # 26764200 Wu, P. et al. 2016. American journal of physiology. Renal physiology. ajprenal.00270.2015.
PMID: # 23948706 Ulrich, C. et al. 2013. American journal of physiology. Cell physiology. 305: C803-16.
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