LY 487379 hydrochlorideA positive allosteric modulator selective for mGluR-2

LY 487379 hydrochloride (CAS 353229-59-1)

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Synonym: 2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide hydrochloride
Application: A positive allosteric modulator selective for mGluR-2
CAS Number: 353229-59-1
Molecular Weight: 488.91
Molecular Formula: C21H19F3N2O4S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY 487379 hydrochloride is a positive allosteric modulator selective for mGluR-2. LY 487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 µM for mGluR-2 and mGluR-3 receptors respectively). LY 487379 hydrochloride is devoid of any activity at mGluR-5 and mGluR-7.


References

Johnson et al (2003) Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,-trifluoroethylsulfonyl)pyrid-3-ylmethyl-amine. J.Med.Chem. 46 3189. Schaffhauser et al (2003) Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol.Pharmacol. 64 798. Poisik et al (2005) Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology 49 57.

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56972206
SMILES :
COC1=CC=CC=C1OC2=CC=C(C=C2)N(CC3=CN=CC=C3)S(=O)(=O)CC(F)(F)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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