LY 487379 hydrochloride is a positive allosteric modulator selective for mGluR-2. LY 487379 hydrochloride potentiates glutamate-stimulated [35S]GTPγS binding (EC50 values are 1.7 and > 10 µM for mGluR-2 and mGluR-3 receptors respectively). LY 487379 hydrochloride is devoid of any activity at mGluR-5 and mGluR-7.
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