LY 354740 is a highly selective and potent mGluR-2/3 (group II mGlu receptor) agonist. LY 354740 has been shown to be a conformationally constrained analog of glutamate with the ability to decrease forskolin-stimulated cAMP formation by more than 90%. Recent studies have found that activation of presynaptic metabotropic mGluR-2/3 induces long lasting inhibition of P/Q-type Ca2+ channels and the cAMP/protein kinase A pathway.
1. Schaffhauser, H., et al. 1997. Eur. J. Pharmacol. 334h: 289-297. PMID: 9369360 2. Schoepp, D.D., et al. 1997. Neuropharmacology. 36: 1-11. PMID: 9144636 2. Helton, D.R., et al. 1998. J. Pharmacol. Exp. Ther. 284: 651-660. PMID: 9454811 3. Klodzinska, A., et al. 1999. Neuropharmacology. 38: 1831-1839. PMID: 10608278
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OrlandoOrlando, R. et al. (PubMed 25063582) reported that levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY 379268 and LY 354740. -SCBT Publication Review
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