LY 171883A selective leukotriene D4 antagonist

LY 171883 (CAS 88107-10-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 70ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A selective leukotriene D4 antagonist
CAS Number: 88107-10-2
Molecular Weight: 318.4
Molecular Formula: C16H22N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

LY 171883, a CysLT1 Receptor (leukotriene D4) antagonist, has been shown to displace oleic acid (sc-200797) binding to fatty-acid-binding protein (FABP) which may be involved in fatty acid metabolism. Studies suggest that this compound contains structural similarity to fatty acids, hence the ability to bind to FABPs. Additional data suggests that LY 171883 causes membrane hyperpolarization and reduces firing rate of action potentials in neuroblastoma cells in vitro. LY 171883 is an inhibitor of PDE and an activator of PPAR α and PPAR γ.


1. Fleisch, J.H., et al. 1985. J. Pharmacol. Exp. Ther. 233: 148-157. PMID: 3981452
2. Aharony, D., et al. 1987. J. Pharmacol. Exp. Ther. 243: 921-926. PMID: 2826761
3. Cannon, J.R. and Eacho, P.I. 1991. Biochem. J. 280: 387-391. PMID: 1747111
4. Li, P.C., et al. 2002. J. Cell. Physiol. 192: 188-199. PMID: 12115725

Physical State :
Solubility :
Soluble in ethanol (25 mg/ml), DMSO (101 mM), DMF, 0.5M aqueous sodium bicarbonate, and water (15 mg/ml).
Storage :
Store at room temperature
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Cavia porcellus: IC50 = 1.5 µM; 5-LO: IC50 = 18.9 µM (human); Arachidonate 5-lipoxygenase: IC50 = 18.9 µM (rat); PDE: IC50 = 22.6 µM (human); Cox: IC50 = 44 µM (human)
Ki Data :
CysLT1 Receptor: Ki= 60 nM (human); 3H-LTD4 binding to guinea pig lung membranes: Ki= 0.63 µM
pK Values :
pKa: 5.4 (Predicted), pKb: 1.44 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 61ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 39ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.