Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Luteolin is an inhibitor of Cot, PDE1-5, c-Src, HDAC, Maltase-glucoamylase, Topo I, PKC ε, Fatty Acid Synthase, PPAR γ and MMP.
1. Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16: 43-48. PMID: 8299995 2. Shimoi, L., et al. 1994. Carcinogenesis. 15: 2669-2672. PMID: 7955124 3. Plaumann, B., et al. 1996. Oncogene. 13: 1605-1614. PMID: 8895505 4. Korkina, L.G. and Afanasev, I.B. 1997. Adv. Pharmacol. 38: 151-163. PMID: 8895808
Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO, 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml at 25° C), and methanol.
i have a question "is luteolin soluability in nonpolar solvent? if your answer is yes please which nonpolar solvent?
Asked by: ahmadi
Thank you for your question. Luteolin is soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO (7 mg/ml), 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (~1 mg/ml), water (1 mg/ml) at 25 degrees C, and methanol.
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