LU AA33810CAS: 304008-29-5
MF: C19H25N3O2S3
MW: 423.62
A potent NPY5-R antagonist.

LU AA33810 (CAS 304008-29-5)

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Synonym: N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Application: A potent NPY5-R antagonist
CAS Number: 304008-29-5
Molecular Weight: 423.62
Molecular Formula: C19H25N3O2S3
* Refer to Certificate of Analysis for lot specific data (including water content).
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LU AA33810 is a potent NPY5-R antagonist. Displays ≥ 3300-fold affinity for NPY5-R over NPY1-R, NPY2-R and NPY4-R. LU AA33810 also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. Neuropeptide Y (NPY) receptors belong to the Gi/o-protein-coupled receptor family in four subtypes, NPY1-R, NPY2-R, NPY4-R, NPY5-R, which are found in high concentrations in the brain and in the colon.


References

Walker et al (2009) The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress anxiety. J.Pharmacol.Exp.Ther. 328 900.

Physical State :
Solid
Solubility :
DMSO (100mM)
Storage :
Store at room temperature
Boiling Point :
~640.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
C1=CC=C2C(=C1)C3=C(CCS2)SC(=N3)N([H])[[email protected]@H]4CCC(CC4)N([H])[S](O)(O)C

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Certificate of Analysis

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