LTB4 (Leukotriene B4)A potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin

LTB4 (Leukotriene B4) (CAS 71160-24-2)

LTB4 (Leukotriene B4) | CAS 71160-24-2 is rated 5.0 out of 5 by 1.
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Synonym: 5,12-dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate; 5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
Application: A potent chemokine with roles in inflammation, immunology, the nervous system, brain and skin
CAS Number: 71160-24-2
Purity: ≥98%
Molecular Weight: 336.46
Molecular Formula: C20H32O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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LTB4 (Leukotriene B4) is a potent, eicosanoid lipid mediator that plays numerous roles in inflammation, immunological functions and maintenance of biological homeostasis. Leukotrienes primarily act through specific G protein-coupled receptors. LTB4 has been found in myeloid cells and is biosynthesized from arachidonic acid. It has been shown to stimulate leukocyte functions including chemokinesis, chemotaxis, lysosomal enzyme release, superoxide anion production, adhesion to endothelial cells, C3b receptor expression, CD11b up-regulation, generation of ROS, induction of the IL-2 receptor and IL-2 production. The chemokine has also been observed to enhance activation, proliferation and differentiation of human B-lymphocytes, T-lymphocytes, granulocytes, macrophages, monocytes, eosinophils, NK cells and to induce vascular permeability, hyperalgesia, and broncho-constriction. In the nervous system and the brain it is involved in the modulation of the ryanodine receptor and the activation of the capsaicin receptor. On the skin LTB4 is involved in melanocyte pigmentation. The compound has also been found to attenuate inflammation through binding of orphan receptor PPARα. LTB4 (Leukotriene B4) is an activator of P2Y7 and LTB4R2.


References

1. Goetzl, E.J. and Pickett, W.C. 1980. J. Immunol. 125: 1789-1791. PMID: 7410854
2. Ford-Hutchinson, A.W., et al. 1980. Nature. 286: 264-265. PMID: 6250050
3. Dahlén, S.E., et al. 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 3887-3891. PMID: 6267608
4. Serhan, C.N., et al. 1982. Biochem. Biophys. Res. Commun. 107: 1006-1012. PMID: 6291511
5. Nagy, L., et al. 1982. Clin. Exp. Immunol. 47: 541-547. PMID: 6282507
6. Showell, H.J., et al. 1982. J. Immunol. 128: 811-816. PMID: 6274960
7. Flechner, S.M., et al. 1986. Transplant. Proc. 18: 44-51. PMID: 3515693
8. Yamaoka, K.A., et al. 1989. J. Immunol. 143: 1996-2000. PMID: 2550549
9. Martin, H.A. 1990. Brain Res. 509: 273-279. PMID: 2157521
10. Lindström, P., et al. 1990. Scand. J. Immunol. 31: 737-744. PMID: 1972589
11. Yokomizo, T., et al. 2001. Arch. Biochem. Biophys. 385: 231-241. PMID: 11368003
12. Funk, C.D. 2001. Science. 294: 1871-1875. PMID: 11729303

Formulation :
50 µg/ml in ethanol
Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in methanol, ethanol, PBS(pH 7.2) (1 mg/ml), DMSO, and DMF.
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.53
IC50 :
Leukotriene B4 receptor 2: IC50 = 1.9 nM (human)
Ki Data :
Leukotriene B4 receptor 1: Ki= 1.9 nM (human); Leukotriene B4 receptor 2: Ki= 0.12 nM (human)
pK Values :
pKa: 4.66
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
JX3852000
PubChem CID :
5280492
Merck Index :
14: 5455
MDL Number :
MFCD00135630
SMILES :
CCCCC/C=C\\C[C@H](/C=C/C=C/C=C\\[C@H](CCCC(=O)O)O)O

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Certificate of Analysis

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LTB4 (Leukotriene B4)  Product Citations

See how others have used LTB4 (Leukotriene B4). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27044800  Uehara, S. et al. 2016. Drug Metab. Dispos. 44: 833-41.

PMID: # 25573892  Torraca, V. et al. 2015. Dis Model Mech. 8: 253-69.

PMID: # 25554564  Capannolo, M. et al. 2015. Eur Neuropsychopharmacol. 25: 413-24.

Citations 1 to 3 of 3 total

How is it synthetized?

Asked by: Yoss
Thank you for your message. Please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-27

What is the appearance?

Asked by: SCchem16
Thank you for your question. LTB4 (Leukotriene B4) (CAS 71160-24-2) is supplied as a colorless liquid.
Answered by: Chemical Support 2
Date published: 2017-03-08

What is the concentration of the A size?

Asked by: SCchem16
Thank you for your question. This chemical, LTB4 (Leukotriene B4): sc-201043, has a concentration of 1mg/ml in ethanol when you order the A size.
Answered by: Chemical Support 2
Date published: 2017-03-08

How long is this stable for?

Asked by: SCchem16
Thank you for your question.This chemical, LTB4 (Leukotriene B4) (CAS 71160-24-2), is stable for at least 1 year after receipt when stored, as supplied, at -80°C.
Answered by: Chemical Support 2
Date published: 2017-03-08
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Rated 5 out of 5 by from Linstrom et al Linstrom et al. (PubMed ID 1972589) showed that leukotriene B4 induced a transient expression of hyperadhesiveness in cultured human umbilical chord endothelial cells (HUVEC) and neutrophils. -SCBT Publication Review
Date published: 2015-02-18
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