LoxoribineCAS: 121288-39-9
MF: C13H17N5O6
MW: 339.3
Agonist for TLR7 (Toll-like receptor 7).

Loxoribine (CAS 121288-39-9)

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Synonym: 7-Allyl-7,8-dihydro-8-oxoguanosine
Application: Agonist for TLR7 (Toll-like receptor 7)
CAS Number: 121288-39-9
Purity: ≥97%
Molecular Weight: 339.3
Molecular Formula: C13H17N5O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Loxoribine is a selective agonist for TLR7 (Toll-like receptor 7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2. Loxoribine is a very potent immunostimulatory compound that increases cytokine production and possesses antitumor and antiviral properties.


References

Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol. 151, 3007 (1993) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle: M.G. Goodman, et al.; Blood 84, 3457 (1994) Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression: U. Schindler and V.R. Baichwal; Mol. Cell. Biol. 14, 5820 (1994) The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell. Immunol. 162, 333 (1995) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7: J. Lee, et al.; PNAS 100, 6646 (2003) Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN: I.B. Bekeredjian-Ding, et al.; J. Immunol. 174, 4043 (2005)

Physical State :
Solid
Solubility :
Soluble in DMSO (30 mg/ml), water (10 mg/ml), water:acetonitrile (1:1) (20 mg/ml), and water:methanol (1:1) (10 mg/ml).
Storage :
Store at -20° C
Melting Point :
227-230° C (lit.)
Boiling Point :
591.75° C at 760 mmHg (Predicted)
Density :
1.93 g/cm3 (Predicted)
Refractive Index :
n20D 1.81 (Predicted)
Optical Activity :
α21/D -32°, c = 1 in water
pK Values :
pKa: 3.78 (Predicted), pKb: 9.88 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
60737
MDL Number :
MFCD00867591
SMILES :
C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O

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Certificate of Analysis

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At what concentration does Loxoribine act as an agonist for TLR7 (Toll-like receptor 7)? 

Asked by: SCM4
The publication “TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway.” by Liu et. al. (PMID: 23843519) states that Loxoribine is an agonist of TLR7 at a concentration of 1mM.
Answered by: Tech Service 11
Date published: 2017-03-02
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