LoxoprofenA non-steroidal anti-inflammatory compound

Loxoprofen (CAS 68767-14-6)

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Synonym: α-Methyl-4-[(2-oxocyclopentyl)methyl]benzeneacetic acid
Application: A non-steroidal anti-inflammatory compound
CAS Number: 68767-14-6
Molecular Weight: 246.30
Molecular Formula: C15H18O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Loxoprofen is a non-steroidal anti-inflammatory drug that is quickly converted to the trans-alcohol metabolite. It is similar to ibuprofen and naproxen, while also being a COX (Cycloxygenase) inhibitor. Loxoprofen is an inhibitor of Cox-1 and Cox-2.


References

Matsumoto M. Neuroscience letters (2006), 397(3), 249-53.

Physical State :
Solid
Solubility :
Soluble in water (0.81 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
108.5-111° C
Boiling Point :
417.86° C
Density :
1.18 g/cm3
Refractive Index :
n20D 1.57
IC50 :
Cox-1: IC50 = 6.5 µM (human); Cox-2: IC50 = 10 µM (human)
pK Values :
pKa: 4.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3965
Merck Index :
14: 5589
MDL Number :
MFCD00864331
SMILES :
CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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