Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine has been shown to induce p53 expression.
1. Dean, S.W., et al. 1986. Biochem. Pharmacol. 35: 1171-1176. PMID: 2938589 2. Hartley, J.A., et al. 1986. Cancer Res. 46: 1943-1947. PMID: 3004713 3. Brent, T.P. 1986. Cancer Res. 46: 2320-2323. PMID: 2938727 4. Aquilina, G., et al. 2000. Clin. Cancer Res. 6: 671-680. PMID: 10690553
Soluble in ethanol (47 mg/ml at 25° C), chloroform, water (<1 mg/ml at 25° C), DMSO (47 mg/ml at 25° C), and acetone.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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HarveyHarvey, KA. et al. (PubMed 25526274) reported enhanced anticancer properties of Lomustine when combined with docosahexaenoic acid in glioblastoma cell lines. -SCBT Publication Review
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