Lipopolysaccharide, E. coli 055:B5 A component of the cell wall of Gram-negative bacteria.

Lipopolysaccharide, E. coli 055:B5

Lipopolysaccharide, E. coli O55:B5 is rated 5.0 out of 5 by 2.
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Alternate Names: Lipopolysaccharide, E. coli O55:B5 is also known as LPS E. coli O55:B5.
Application: Lipopolysaccharide, E. coli O55:B5 is a component of the cell wall of Gram-negative bacteria and Specific activator of Toll-like receptor (TLR) 4.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Lipopolysaccharide, E. coli O55:B5 is a component of the cell wall of the O55:B5 serotype of the Gram-negative bacteria, Escherichia coli. Lipopolysaccharides (LPS) are made up of a hydrophobic lipid, a hydrophilic core polysaccharide chain and a hydrophilic O-antigenic polysaccharide side chain. LPS molecules contribute to the outer integrity of the cell membrane, protect the cell against bile salts and lipophilic antibiotics, and act as endotoxins in animals. LPS induces a strong immune response by binding to the CD14/TLR4/MD2 receptor complex, which promotes the secretion of pro-inflammatory cytokines. LPS is also an exogenous pyrogen. LPS O55:B5 has been derived from a serotype of E. coli O55:B5, which is part of a subdivision based on the O antigen component of LPS. Lipopolysaccharide, E. coli O55:B5 is a form of lipopolysaccharide (LPS) extracted from wild-type S-form E. coli serotype O55:B5. Lipopolysaccharide, E. coli O55:B5 is commonly used to activate toll-like receptor 4 (TLR4) on leukocytes, eliciting inflammatory signaling in isolated cells and in vivo.1,2,3,4 Lipopolysaccharide, E. coli O55:B5 includes three regions, the O-antigenic polysaccharide chain, the core oligosaccharide, and lipid A. Lipopolysaccharide, E. coli O55:B5 stimulates the activity of inducible nitric oxide synthase. Lipopolysaccharide, E. coli O55:B5 induces apoptosis in mouse thymus and swine lymphocytes. Lipopolysaccharide, E. coli O55:B5 is also known as LPS.


References

1. Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
2. Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
3. Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
4. Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
5. Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
6. Brauer, R.B., Gegenfurtner, C., Neumann, B., et al.Endotoxin-induced lung inflammation is independent of the complement membrane attack complex. Infection and Immunity 68(3), 1626-1632 (2000).
7. Jungi, T.W., Sager, H., Adler, H., et al.Serum factors, cell membrane CD14, and β2 integrins are not required for activation of bovine macrophages by lipopolysaccharide. Infection and Immunity 65(9), 3577-3584 (1997).
8. Li, C.C., Munitic, I., Mittelstadt, P.R., et al.Suppression of dendritic cell-derived IL-12 by endogenous glucocorticoids is protective in LPS-induced sepsis. PLOS Biology 13(10), (2015).
9. Migale, R., Herbert, B.R., Lee, Y.S., et al.Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor. Am. J. Pathol. 185(9), 2390-2401 (2015).

Appearance :
Lyophilized powder
Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JZ2650000
MDL Number :
MFCD00164401

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Certificate of Analysis

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Lipopolysaccharide, E. coli 055:B5  Product Citations

See how others have used Lipopolysaccharide, E. coli 055:B5. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 30770245  Arora, H. et al. 2019. Immunity.

PMID: # 29248540  Wang, P.|Zhang, Y.|Gong, Y.|Yang, R.|Chen, Z.|Hu, W.|Wu, Y.|Gao, M.|Xu, X.|Qin, Y.|Huang, C.| et al. 2018. Neurobiol. Dis. 111: 12-25.

PMID: # 29897333  Oikonomidi, I.|Burbridge, E.|Cavadas, M.|Sullivan, G.|Collis, B.|Naegele, H.|Clancy, D.|Brezinova, J.|Hu, T.|Bileck, A.|Gerner, C.|Bolado, A.|von Kriegsheim, A.|Martin, SJ.|Steinberg, F.|Strisovsky, K.|Adrain, C.| et al. 2018. Elife. 7:

PMID: # 29045841  Cavadas, M.|Oikonomidi, I.|Gaspar, CJ.|Burbridge, E.|Badenes, M.|Félix, I.|Bolado, A.|Hu, T.|Bileck, A.|Gerner, C.|Domingos, PM.|von Kriegsheim, A.|Adrain, C.| et al. 2017. Cell Rep. 21: 745-757.

PMID: # 27381299  Frick, L. et al. 2016. Brain Behav. Immun. 57: 326-37.

PMID: # 24704101  Qin, J. et al. 2014. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 58: 63-71.

PMID: # 29976869  Int J Mol Sci. 19:

Citations 1 to 7 of 7 total

What is the estimated molecular weight of Lipopolysaccharide, E. coli 055:B5?

Asked by: J_So
Thank you for your question. Unfortunately we are not able to perform any molecular weight analysis for this product. If you have any further questions, please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-06-09

What temperature should this be stored at after reconstitution?

Asked by: SCchem16
Thank you for your question. For this chemical, Lipopolysaccharide, E. coli 055:B5, we always recommend using stock solutions the same day, however, it can be stored at 4°C. Aqueous stock solutions are stable for up to 6 months at 4°C.
Answered by: Chemical Support 2
Date published: 2017-03-02
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Rated 5 out of 5 by from works perfect! I bought this reagent one month ago, it works perfect on RAW264.7 cells.
Date published: 2019-04-24
Rated 5 out of 5 by from Beckel Beckel, JM. et al. (PubMed 25630792) found that intravesical instillation of lipopolysaccharide, E. coli 055:B5 increased ATP concentrations in the bladder perfusate, and also increased voiding frequency; these effects were suppressed by Brilliant Blue FCF. -SCBT Publication Review
Date published: 2015-04-18
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