LicofeloneCAS: 156897-06-2
MF: C23H22ClNO2
MW: 379.88
An inhibitor of Cox-1, Cox-2, and 5-lipoxygenase.

Licofelone (CAS 156897-06-2)

Licofelone | CAS 156897-06-2 is rated 5.0 out of 5 by 1.
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Synonym: ML-3000
Application: An inhibitor of Cox-1, Cox-2, and 5-lipoxygenase
CAS Number: 156897-06-2
Purity: ≥99%
Molecular Weight: 379.88
Molecular Formula: C23H22ClNO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Licofelone is an anti-inflammatory and dual inhibitor of cyclooxygenase and 5-LO(5-lipoxygenase). Licofelone inhibits both Cox-1 and Cox-2.


References

Laufer, S.A., et al.: J. Med. Chem., 37, 1894 (1994) Tries, S., et al.: Inflamm. Res., 51, 135 (2002) Moreau, M., et al.: J. Vet. Pharmacol. Ther., 28, 81 (2005),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (~5 mg/ml), DMSO (20 mg/ml), DMF (20 mg/ml), and methanol. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
165-167° C
Boiling Point :
~539.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Thrombocyte COX: IC50 = 0.16 µM (human); Cox-1: IC50 = 0.16 µM (human); 5-LO: IC50 = 0.23 µM (human); Cox-2: IC50 = 0.37 µM (human); PGE synthase: IC50 = 3.9 mM (human)
pK Values :
pKa: 4.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
133021
MDL Number :
MFCD00929900
Beilstein Registry :
6823674
SMILES :
CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C

Download SDS (MSDS)

Certificate of Analysis

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Licofelone  Product Citations

See how others have used Licofelone. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25200318  Zhang, K. et al. 2015. European journal of orthopaedic surgery & traumatology : orthopdie traumatologie. 25 Suppl 1: S63-8.

PMID: # 23303944  Dulin, JN. et al. 2013. J. Neurosci. 33: 652-64.

PMID: # 22947335  Dulin, JN. et al. 2013. J. Neurotrauma. 30: 211-26.

Citations 1 to 3 of 3 total

Is the compound soluble in DCM or THF?

Asked by: Raed
Thank you for your question. This biochemical compound is soluble in water (0.5 mg/ml at 25° C), ethanol (~5 mg/ml), DMSO (20 mg/ml), DMF (20 mg/ml), and methanol. I do not have information regarding solubility in THF.
Answered by: Tech Service
Date published: 2019-10-31

What is the solubility of this chemical in methanol?

Asked by: two2igm05
Thank you for you question. Licofelone, sc-207826, is soluble in methanol, but we don't know at which concentration. However, it is soluble in DMSO at 76 mg/mL (200.06 mM), Ethanol at 10 mg/mL (26.32 mM), and Water at <1 mg/mL (<1 mM).
Answered by: TechService7
Date published: 2016-12-19

Hello, this is my first time on the new website. I've been able to request bulk purchase pricing for licofelone (sc-207826) in the past, but am unable to see a link that would allow me to do that here. Is this an option that is no longer available?

Asked by: Ray Grill
Thank you for your interest in this product (sc-207826). We are happy to provide you with a quote for a bulk purchase. Please contact our Special Orders Department by email, [email protected] Or by phone, 800-457-3801 option 2 for Technical Support, and ask to speak with one of our Special Orders Coordinators. If you wish to request a quote directly through our website, please connect with us using our Live Chat!
Answered by: Technical Support
Date published: 2016-09-07
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Rated 5 out of 5 by from Payandemehr et al Payandemehr et al. (PubMed ID 26216049) found that the COX inhibitor, licofelone, exhibited anticonvulsive properties in mice via the downregulation of nitric oxide synthase. -SCBT Publication Review
Date published: 2015-05-14
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