LHX1 Antibody (2A8): sc-293475
- LHX1 Antibody (2A8) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against amino acids 1-100 representing partial length LHX1 of human origin
- recommended for detection of LHX1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LHX1 Antibody (2A8). This work is in progress.
LHX1 Antibody (2A8) is a mouse monoclonal IgG2a antibody that detects LHX1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). LHX1 plays a crucial role in the development of motor neurons by regulating the expression of specific LIM-type homeodomain factors, which are essential for guiding motor axons and ensuring the correct trajectory during neural development. LHX1 is primarily located in the nucleus, where LHX1 influences gene expression patterns that are vital for neuronal differentiation and the establishment of motor neuron subtypes. The precise localization of LHX1 within the nucleus is important because LHX1 allows for the effective regulation of target genes involved in motor neuron development, thereby impacting the overall functionality of the nervous system. The human LHX1 gene, which encodes a 384 amino acid protein, is mapped to chromosome 11p13-p12 and is composed of five exons, with the LIM domains and homeodomain strategically positioned across these exons. Anti-LHX1 antibody (2A8) is an invaluable tool for researchers studying motor neuron development and related neurological disorders, providing insights into the molecular mechanisms underlying neuronal differentiation and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LHX1 Antibody (2A8) References:
- Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. | Pillai, A., et al. 2007. Development. 134: 357-66. PMID: 17166926
- Lhx1 is required for specification of the renal progenitor cell field. | Cirio, MC., et al. 2011. PLoS One. 6: e18858. PMID: 21526205
- LHX1 mutation screening in 96 patients with müllerian duct abnormalities. | Xia, M., et al. 2012. Fertil Steril. 97: 682-5. PMID: 22217964
- Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. | Bedont, JL., et al. 2014. Cell Rep. 7: 609-22. PMID: 24767996
- The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. | Espiritu, EB., et al. 2018. Sci Rep. 8: 16029. PMID: 30375416
- Mechanistic insights from the LHX1-driven molecular network in building the embryonic head. | McMahon, R., et al. 2019. Dev Growth Differ. 61: 327-336. PMID: 31111476
- Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks. | Symmank, J., et al. 2020. Epigenetics. 15: 1259-1274. PMID: 32441560
- LHX1 as a potential biomarker regulates EMT induction and cellular behaviors in uterine corpus endometrial carcinoma. | Tian, Y., et al. 2022. Clinics (Sao Paulo). 77: 100103. PMID: 36116266
- Long non-coding RNA LHX1-DT regulates cardiomyocyte differentiation through H2A.Z-mediated LHX1 transcriptional activation. | Yu, Q., et al. 2023. iScience. 26: 108051. PMID: 37942009
- LIM homeobox 1 (LHX1) induces endoplasmic reticulum stress and promotes preterm birth. | Qiu, L., et al. 2024. Heliyon. 10: e32457. PMID: 39027525
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LHX1 Antibody (2A8) | sc-293475 | 100 µg/ml | $316.00 |