Levonorgestrel CAS: 797-63-7
MF: C21H28O2
MW: 312.45
A synthetic progestin that binds to progesterone and androgen receptors.

Levonorgestrel (CAS 797-63-7)

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Alternate Names: Norplant
Application: Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors
CAS Number: 797-63-7
Molecular Weight: 312.45
Molecular Formula: C21H28O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Levonorgestrel is a synthetic progestin that binds to progesterone and androgen receptors but not the estrogen receptor. Induces apoptosis in ovarian epithelium cells.


References

Lemus AE, Vilchis F, Damsky R. J Steroid Biochem Mol Biol. 41:881-90 (1992). Rodriguez GC, Walmer DK, Cline M et al. J Soc Gynecol Investig. 5:271-6 (1998).

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in ethanol (~0.2 mg/ml), chloroform, DMF (~5 mg/ml), and DMSO (~5 mg/ml). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
240° C
Boiling Point :
~459.1° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Progesterone receptor: IC50 = 3.51 nM (bovine); Androgen Receptor: IC50 = 6.4 nM (rat); GR : IC50 = 149 nM (human); ST: IC50 = 1.12 µM (human)
Ki Data :
Progesterone receptor: Ki= 0.46 nM (bovine); Androgen Receptor: Ki= 4.27 nM (rat); GR : Ki= 68 nM (human); ST: Ki= 595 nM (human)
pK Values :
pKa: 13.09 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
JF8259000
PubChem CID :
Merck Index :
14: 6704
MDL Number :
MFCD00199013
EC Number :
212-349-8
Beilstein Registry :
2391114
SMILES :
CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34

Download SDS (MSDS)

Certificate of Analysis

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