Levobunolol, Hydrochloride CAS: 27912-14-7
MF: C17H26ClNO3
MW: 327.84
A β-adrenoceptor antagonist.

Levobunolol, Hydrochloride (CAS 27912-14-7)

Levobunolol, Hydrochloride | CAS 27912-14-7 is rated 5.0 out of 5 by 1.
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Alternate Names: Vistagan; Akbeta
Application: Levobunolol, Hydrochloride is a β-adrenoceptor antagonist
CAS Number: 27912-14-7
Molecular Weight: 327.84
Molecular Formula: C17H26ClNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Levobunolol, Hydrochloride is a non-selective β-AR (β-adrenoceptor) antagonist.


References

1. Kaplan, HR, et al., 1971. Oral-adrenoreceptor blocking activity of bunolol and its optical isomers. European journal of pharmacology. 16(2): 237-40. PMID: 4405784
2. DiCarlo,F.J., et al., 1977. Metabolism of I-bunolol. Clinical pharmacology & therapeutics. 22(6): 858-63. PMID: 336256

Physical State :
Solid
Solubility :
Soluble in Dimethyl Sulfoxide, Hot Ethanol, Methanol and Water
Storage :
Store at -20° C
Melting Point :
209-211° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C)(C)NC[[email protected]@H](COC1=CC=CC2=C1CCCC2=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Rothwell Rothwell, CE. et al. (PubMed) evaluated the chronic toxicity and carcinogenicity of Levobunolol, a non-selective -adrenoceptor antagonist, in Swiss mice and Wistar rats. In rats, significant body weight gain suppression occurred at 5, 30, and 180 mg/kg. Brown discoloration of perianal fur and steel-gray discoloration of hairless skin were evident in high-dose rats. A generalized steel-gray discoloration of internal organs and tissues occurred in the 30 and 180 mg/kg groups. No other differences between treated and control groups were evident. -SCBT Publication Review
Date published: 2015-04-25
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